934187-86-7

Basic information

• Product Name: 2-[1-(4-chloro-2,6-dimethylphenyl)-6-oxo-1,6-dihydro-3-pyridinyl]-1-(2,4-difluorophenyl)-2-oxoethyl 2,2-bis(hydroxymethyl)butanoate
• CAS NO: 934187-86-7
• Molecular Weight: 533.956
• Mol File: 934187-86-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[1-(4-chloro-2,6-dimethylphenyl)-6-oxo-1,6-dihydro-3-pyridinyl]-1-(2,4-difluorophenyl)-2-oxoethyl 2,2-bis(hydroxymethyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-chloro-2,6-dimethylphenyl)-6-oxo-1,6-dihydro-3-pyridinyl]-1-(2,4-difluorophenyl)-2-oxoethyl 2,2-bis(hydroxymethyl)butanoate(934187-86-7)
• EPA Substance Registry System: 2-[1-(4-chloro-2,6-dimethylphenyl)-6-oxo-1,6-dihydro-3-pyridinyl]-1-(2,4-difluorophenyl)-2-oxoethyl 2,2-bis(hydroxymethyl)butanoate(934187-86-7)

Safety Data

• Hazardous Substances Data: 934187-86-7(Hazardous Substances Data)

Upstream product

• 934187-41-4 5-[bromo(2,4-difluorophenyl)acetyl]-1-(4-chloro-2,6-dimethylphenyl)-2(1H)-pyridinone 
• 10097-02-6 2,2-bis(hydroxymethyl)butanoic acid 

Relevant articles and documents

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF

It is intended to provide a compound represented by the general formula (I): (I) (wherein all the symbols are as defined in the description) which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.