1009813-29-9Relevant academic research and scientific papers
New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations
Moulin, Aline,Demange, Luc,Ryan, Joanne,Mousseaux, Delphine,Sanchez, Pierre,Bergé, Gilbert,Gagne, Didier,Perrissoud, Daniel,Locatelli, Vittorio,Torsello, Antonio,Galleyrand, Jean-Claude,Fehrentz, Jean-Alaín,Martinez, Jean
, p. 689 - 693 (2008)
Ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure were synthesized and evaluated for their in vitro binding and biological activity. In this study, we explored the replacement of the α- aminoisobutyryl moiety by aromatic or heteroaromatic groups. Compounds 5 and 34 acted as potent in vivo antagonists of hexarelin-stimulated food intake. These two compounds did not stimulate growth hormone secretion in rodents and did not antagonize growth hormone secretion induced by hexarelin.
NOVEL 1,2,4-TRIAZOLE DERIVATIVES AND PROCESS OF MANUFACTURING THEREOF
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Page/Page column 43, (2009/10/01)
The invention provides 1,2,4-triazole compounds, compositions containing those compounds, methods of treating diseases and/or disorders with those compounds and processes of manufacturing 1,2,4-triazole compounds.
