100983-03-7

Basic information

• Product Name: 19,19-difluoro-3-oxoandrost-4-en-17β-yl benzoate
• Synonyms: 19,19-difluoro-3-oxoandrost-4-en-17β-yl benzoate
• CAS NO: 100983-03-7
• Molecular Weight: 428.519
• Mol File: 100983-03-7.mol

Chemical Properties

• CAS DataBase Reference: 19,19-difluoro-3-oxoandrost-4-en-17β-yl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 19,19-difluoro-3-oxoandrost-4-en-17β-yl benzoate(100983-03-7)
• EPA Substance Registry System: 19,19-difluoro-3-oxoandrost-4-en-17β-yl benzoate(100983-03-7)

Safety Data

• Hazardous Substances Data: 100983-03-7(Hazardous Substances Data)

Upstream product

• 986-02-7 3,19-dioxoandrost-4-en-17β-yl benzoate 
• 20155-05-9 17β,19-dihydroxy-androst-4-en-3-one 17-benzoate 

Downstream Products

• 127301-85-3 3,3-ethylenedioxy-19,19-difluoroandrost-5-ene-17β-ol benzoate 
• 7764-45-6 19,19-difluoroandrost-4-ene-3,17-dione 

Relevant articles and documents

Synthesis of 19,19-Difluoro Steroids and of Novel B-Ring-expanded Steroids

A site-selective fluorination of 10-formylnortestosterone 17-benzoate (4) which allows access to 19,19-difluoro steroids is described, and an associated rearrangement reaction yields the novel abeo-testosterone derivative (6) and thence the homoestradiol

Preparation of Aromatase Inhibitors. Synthesis of 19,19-Difluoro-4-hydroxyandrost-4-ene-3,17-dione and Related Compounds

A new route to 19,19-difluoroandrost-4-ene-3,17-dione (2) has been devised, in which the key step is the reaction of (diethylamino)sulphur trifluoride (DAST) with 3,19-dioxandrost-4-en-17β-yl benzoate (5).A novel rearrangement product (7) was also produced in this reaction.Compound (2) and its 4-hydroxy derivative (3; R=H) inhibited human placental aromatase in vitro, but were not as potent as 4-hydroxyandrost-4-ene-3,17-dione (1).