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19,19-Difluoroandrost-4-ene-3,17-dione is a synthetic steroid compound characterized by the presence of two fluorine atoms at the 19th carbon position and a double bond between the 4th and 5th carbon atoms. This molecule features a ketone group at both the 3rd and 17th carbon positions, which are key structural elements in steroid chemistry. It is derived from the androstane skeleton, a common structure in many natural and synthetic steroids. 19,19-difluoroandrost-4-ene-3,17-dione is of interest in the field of medicinal chemistry, particularly for its potential applications in the development of drugs that target steroid hormone receptors, due to its unique substitution pattern that can influence its biological activity and selectivity.

7764-45-6

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7764-45-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7764-45-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,6 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 7764-45:
(6*7)+(5*7)+(4*6)+(3*4)+(2*4)+(1*5)=126
126 % 10 = 6
So 7764-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H24F2O2/c1-18-8-7-15-13(14(18)4-5-16(18)23)3-2-11-10-12(22)6-9-19(11,15)17(20)21/h10,13-15,17H,2-9H2,1H3/t13-,14-,15-,18-,19+/m0/s1

7764-45-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name (8S,9S,10S,13S,14S)-10-(difluoromethyl)-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione

1.2 Other means of identification

Product number -
Other names 19,19-Dfad

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7764-45-6 SDS

7764-45-6Relevant academic research and scientific papers

STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF

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Paragraph 0245-0246, (2020/12/22)

The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound as shown in formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and uses thereof as a regulator of GABA A receptor for treating depression, convulsion, Parkinson's disease, and nervous system diseases, wherein the substituents of the formula (I) are as defined in the description.

Preparation of Aromatase Inhibitors. Synthesis of 19,19-Difluoro-4-hydroxyandrost-4-ene-3,17-dione and Related Compounds

Mann, John,Pietrzak, Barbara

, p. 385 - 388 (2007/10/02)

A new route to 19,19-difluoroandrost-4-ene-3,17-dione (2) has been devised, in which the key step is the reaction of (diethylamino)sulphur trifluoride (DAST) with 3,19-dioxandrost-4-en-17β-yl benzoate (5).A novel rearrangement product (7) was also produced in this reaction.Compound (2) and its 4-hydroxy derivative (3; R=H) inhibited human placental aromatase in vitro, but were not as potent as 4-hydroxyandrost-4-ene-3,17-dione (1).

Synthesis of 19,19-Difluoro Steroids and of Novel B-Ring-expanded Steroids

Drew, Michael G. B.,Mann, John,Pietrzak, Barbara

, p. 1191 - 1192 (2007/10/02)

A site-selective fluorination of 10-formylnortestosterone 17-benzoate (4) which allows access to 19,19-difluoro steroids is described, and an associated rearrangement reaction yields the novel abeo-testosterone derivative (6) and thence the homoestradiol

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