100990-01-0Relevant articles and documents
One-pot oxidation and bromination of 3,4-diaryl-2,5-dihydrothiophenes using Br2: Synthesis and application of 3,4-diaryl-2,5-dibromothiophenes
Dang, Yizhe,Chen, Yi
, p. 6901 - 6904 (2008/02/11)
(Chemical Equation Presented) A class of 3,4-diaryl-2,5-dibromothiophenes (1b-5b) was synthesized by a one-pot reaction of 3,4-diaryl-2,5- dihydrothiophenes with Br2 reagent in excellent yield (83-92%). It was found that Br2 performed a double function (oxidation and bromination) during the conversion of 3,4-diaryl-2,5-dihydrothiophenes to 3,4-diaryl-2,5-dibromothiophenes. The application of 3,4-diaryl-2,5- dibromothiophenes used as building blocks was also investigated. Employing 3,4-diphenyl-2,5-dibromothiophene (1b) as a template, a class of 2,3,4,5-tetraarylthiophenes was prepared by the Suzuki coupling reaction. This provided a new and simple approach to the preparation of 2,3,4,5- tetraarylthiophenes.
GENERAL SYNTHESIS OF 2,5-DIHYDROTHIOPHENES (3-THIOLENES) FROM DIKETO SULFIDES
Nakayama, Juzo,Machida, Haruki,Hoshino, Masamatsu
, p. 1981 - 1982 (2007/10/02)
The intramolecular reductive coupling reaction of easily accesible diketo sulfides by a low-valent titanium reagent (prepared from titanium(IV) chloride and zinc powder) provides an efficient general synthesis of 2,5-dihydrothiophenes.