100993-14-4

Upstream product

• 585-34-2 3-tert-butylphenyol 
• 951-98-4 2-Oxo-propionic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 951-98-4 (+)-menthyl pyruvate 

Downstream Products

• 113322-89-7 (2S)-2-(2-hydroxy-4-tert-butylphenyl)-1,2-dihydroxypropane 
• 113322-92-2 (2S)-2-hydroxy-2-(2-hydroxy-4-tert-butylphenyl)propanoic acid 

Relevant academic research and scientific papers

Asymmetric Electrophilic Substitution on Phenols. 2. Enantio- and Diastereoselective Synthesis of o-Hydroxyatrolactic Esters

Both 2R and 2S stereoisomers of o-hydroxyatrolactic acid esters 3-5 are available with respective absolute configuration from phenols 1 and pyruvic acid esters 2 by using menthol only as a chiral inductor.Three asymmetric approaches were designed based on

HIGHLY STEREOCONTROLLED SUBSTITUTION OF PHENOLS WITH PYRUVIC ESTERS. A VIABLE ROUTE TO ortho-HYDROXYATROLACTIC ESTERS OF (2R)- AND (2S)-CONFIGURATION

Treatment of phenols with optically active (+)- and (-)-menthyl pyruvate assisted by Al(III)- or Ti(IV)-based promoters leads to the formation of ortho-hydroxyatrolactic esters of (2R)- and (2S)-configuration.The use of suitable menthol-based promoters au