101-22-4

Usage

General Description

Urea, N,N'-bis(3-aminophenyl)-, is a chemical compound with a molecular structure characterized by two 3-aminophenyl groups linked by a urea bridge. It holds significance in the field of organic chemistry and materials science, serving as a building block for the synthesis of various organic molecules and polymers. The presence of amino groups on the phenyl rings enhances its reactivity and makes it valuable in the creation of functionalized compounds with diverse applications, including pharmaceuticals, dyes, and specialty chemicals. Its ability to participate in versatile chemical reactions allows for the design and development of complex molecules with tailored properties, contributing to advancements in various industrial and scientific disciplines.

Upstream product

• 1234-21-5 1,3-bis(3-nitrophenyl)urea 
• 99-09-2 3-nitro-aniline 
• 3320-87-4 isocyanic acid (3-nitro-phenyl) ester 

Downstream Products

• 53357-12-3 1,3-Bis-(3-amino-4-thiocyanato-phenyl)-urea 
• 96615-82-6 1,3-Bis-[3-(4,6-diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl)-phenyl]-urea; hydrochloride 
• 1279692-22-6 1,3-bis(3-{[(2-methylphenyl)carbamoyl]amino}phenyl)urea 
• 1160839-62-2 N,N'-bis(3-(3-nitrobenzamido)phenyl)urea 
• 92-62-6 proflavine 

Relevant academic research and scientific papers

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors

Efficacy of currently approved anti-HIV drugs is hampered by mutations of the viral enzymes, leading invariably to drug resistance and chemotherapy failure. Recent data suggest that cellular co-factors also represent useful targets for anti-HIV therapy. H

COMPOUNDS WITH DDX3 INHIBITORY ACTIVITY AND USES THEREOF

The present invention relates to the medical use of the compound of formula 1,2,3 or 4

An 'inside-out' approach to suramin analogues

An approach to the synthesis of suramin analogues has been realised, which avoids synthetic problems associated with conventional routes. The use of isobutyl ester protecting groups for sulfonic acids was crucial to the success of the strategy, because these were able to be cleanly deprotected with sodium iodide, yielding the sodium salts of the corresponding sulfonic acids.

Novel Bis as Antitrypanosomal Agents

A series of novel 1,1'-(4,1-phenylene)bis was prepared and evaluated for activity against Trypanosoma rhodesiense in mice.The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed.The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends encouragement to further development of this structural class.