101-22-4Relevant articles and documents
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: Towards the next generation HIV-1 inhibitors
Radi, Marco,Falchi, Federico,Garbelli, Anna,Samuele, Alberta,Bernardo, Vincenzo,Paolucci, Stefania,Baldanti, Fausto,Schenone, Silvia,Manetti, Fabrizio,Maga, Giovanni,Botta, Maurizio
supporting information; experimental part, p. 2094 - 2098 (2012/04/17)
Efficacy of currently approved anti-HIV drugs is hampered by mutations of the viral enzymes, leading invariably to drug resistance and chemotherapy failure. Recent data suggest that cellular co-factors also represent useful targets for anti-HIV therapy. H
An 'inside-out' approach to suramin analogues
McGeary, Ross P.,Bennett, Andrew J.,Tran, Quoc B.,Prins, Johannes,Ross, Benjamin P.
experimental part, p. 3990 - 3997 (2009/10/09)
An approach to the synthesis of suramin analogues has been realised, which avoids synthetic problems associated with conventional routes. The use of isobutyl ester protecting groups for sulfonic acids was crucial to the success of the strategy, because these were able to be cleanly deprotected with sodium iodide, yielding the sodium salts of the corresponding sulfonic acids.