92-62-6Relevant academic research and scientific papers
ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release
Li, Yingxue,Qi, Xiuxiu,Yan, Hongmei
, p. 29986 - 29996 (2021/10/25)
The atom transfer radical polymerization (ATRP)-based synthesis of a pH-sensitive fluorescent polymer (PSDMA-b-POEGMA) was successfully prepared using 3,6-dibromo-isobutyramide acridine (DIA), an initiator with a fluorescent chromophore, to initiate a lipophilic monomer 2-styryl-1,3-dioxan-5-yl methacrylate (SDMA) and a hydrophilic monomer oligo(ethylene glycol) methyl ether (OEGMA), which contained a cinnamic aldehyde acetal structure. With the addition of hollow mesoporous silicon (HMS@C18), the pH-sensitive core-shell nanoparticles (HMS@C18@PSDMA-b-POEGMA) were developed via a self-assembly process as carriers for the anticancer drug doxorubicin (DOX) for drug loading and controlled release. The nanocomposites showed a higher drug loading capacity which was much higher than that observed using common micelles. At the same time, the polymer coated on the surface of the nanoparticles contains the fluorescent segment of an initiator, which can be used for fluorescence contrast of the cells. The nanocomposite carrier selectively inhibits human melanoma cell A375 relative to human normal fibroblasts GM. The in vitro results suggested that a smart pH sensitive nanoparticles drug delivery system was successfully prepared for potential applications in cancer diagnosis and therapy.
Ultrafast dynamics in co-sensitized photocatalysts under visible and NIR light irradiation
Patwari, Jayita,Chatterjee, Arka,Sardar, Samim,Lemmens, Peter,Pal, Samir Kumar
, p. 10418 - 10429 (2018/04/27)
Co-sensitization to achieve a broad absorption window is a widely accepted technique in light harvesting nanohybrid synthesis. Protoporphyrin (PPIX) and squaraine (SQ2) are two organic sensitizers absorbing in the visible and NIR wavelength regions of the solar spectrum, respectively. In the present study, we have sensitized zinc oxide (ZnO) nanoparticles using PPIX and SQ2 simultaneously for their potential use in broad-band solar light harvesting in photocatalysis. F?rster resonance energy transfer (FRET) from PPIX to SQ2 in close proximity to the ZnO surface has been found to enhance visible light photocatalysis. In order to confirm the effect of intermolecular FRET in photocatalysis, the excited state lifetime of the energy donor dye PPIX has been modulated by inserting d10 (ZnII) and d7 (CoII) metal ions in the central position of the dye (PP(Zn) and PP(Co)). In the case of PP(Co)-SQ2, extensive photo-induced ligand to metal charge transfer counteracts the FRET efficiency while efficient FRET has been observed for the PP(Zn)-SQ2 pair. This observation has been justified by the comparison of the visible light photocatalysis of the respective nanohybrids with several control studies. We have also investigated the NIR photocatalysis of the co-sensitized nanohybrids which reveals that reduced aggregation of SQ2 due to co-sensitization of PPIX increases the NIR photocatalysis. However, core-metalation of PPIX reduces the NIR photocatalytic efficacy, most probably due to excited state charge transfer from SQ2 to the metal centre of PP(Co)/PP(Zn) through the conduction band of the host ZnO nanoparticles.
CO-CRYSTALS AND SALTS OF CONTRAST AGENTS AND IMAGING
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Paragraph 0147, (2014/02/15)
The invention provides co-crystals and salts of contrast agents as well as methods to use and prepare the co-crystals and salts.
