101001-68-7

Basic information

• Product Name: 1-allyl-1H-pyrrole-2-carbaldehyde(SALTDATA: FREE)
• Synonyms: 1-allyl-1H-pyrrole-2-carbaldehyde(SALTDATA: FREE)
• CAS NO: 101001-68-7
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.16316
• Mol File: 101001-68-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 226.303°C at 760 mmHg
• Flash Point: 90.665°C
• Appearance: /
• Density: 0.967g/cm³
• Vapor Pressure: 0.082mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 1-allyl-1H-pyrrole-2-carbaldehyde(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-allyl-1H-pyrrole-2-carbaldehyde(SALTDATA: FREE)(101001-68-7)
• EPA Substance Registry System: 1-allyl-1H-pyrrole-2-carbaldehyde(SALTDATA: FREE)(101001-68-7)

Safety Data

• Hazardous Substances Data: 101001-68-7(Hazardous Substances Data)

Usage

General Description

1-allyl-1H-pyrrole-2-carbaldehyde is a chemical compound with the molecular formula C8H9NO. It is an organic compound that contains a pyrrole ring with an attached aldehyde and allyl group. 1-allyl-1H-pyrrole-2-carbaldehyde(SALTDATA: FREE) is commonly used as a chemical intermediate in the synthesis of various pharmaceuticals and organic compounds. It is also known for its use in the preparation of polymer materials and as a building block in the production of heterocyclic compounds. Additionally, it has potential applications in the field of organic synthesis and as a reagent in chemical reactions. Overall, 1-allyl-1H-pyrrole-2-carbaldehyde is a versatile compound with various applications in the chemical and pharmaceutical industries.

InChI:InChI=1/C8H9NO/c1-2-5-9-6-3-4-8(9)7-10/h2-4,6-7H,1,5H2

Upstream product

• 1003-29-8 2-pyrrole aldehyde 
• 107-05-1 3-chloroprop-1-ene 
• 107-18-6 allyl alcohol 
• 106-95-6 allyl bromide 

Downstream Products

• 389621-00-5 1-cinnamyl-2-pyrrolecarbaldehyde 
• 221675-70-3 Co(octaethylporphyrinate)(C₈H₈NO) 
• 221675-69-0 Co(meso-tetraphenylporphyrinate)(C₈H₈NO) 
• 1432755-24-2 (2S,2aR,14bR,E)-2-phenyl-2a,3,6,7,10,14b-hexahydro-1H-cyclobuta[c]pyrrolo[2,1-e][1,6]oxaazacyclododecin-5(2H)-one 
• 1432755-23-1 ((1R,2R,4S)-2-(1-allyl-1H-pyrrol-2-yl)-4-phenylcyclobutyl)methyl pent-4-enoate 
• 1432755-14-0 ((1R,2R,4S)-2-(1-allyl-1H-pyrrol-2-yl)-4-(4-(trifluoromethyl)phenyl)cyclobutyl)methanol 
• 1432755-13-9 4-((1S,2R,3R)-3-(1-allyl-1H-pyrrol-2-yl)-2-(hydroxymethyl)cyclobutyl)benzonitrile 
• 1432755-12-8 ((1R,2R,4S)-2-(1-allyl-1H-pyrrol-2-yl)-4-(4-fluorophenyl)cyclobutyl)methanol 
• 1432755-11-7 ((1R,2R,4S)-2-(1-allyl-1H-pyrrol-2-yl)-4-(4-bromophenyl)cyclobutyl)methano 
• 1432755-09-3 ((1R,2R,4S)-2-(1-allyl-1H-pyrrol-2-yl)-4-(p-tolyl)cyclobutyl)methanol 
• 1432755-08-2 ((1R,2R,4S)-2-(1-allyl-1H-pyrrol-2-yl)-4-(3-chlorophenyl)cyclobutyl)methanol 

Relevant articles and documents

Synthesis and evaluation of cyclic nitrone derivatives as potential anti-cancer agents

Nitrones have been found to exhibit attractive biological values as immuno spin trapping agents. However, successful clinical cases of nitrone therapeutics are still lacking. Herein we report the synthesis and antiproliferative activity of a series of structurally diverse nitrone derivatives against a panel of 5 cancer cell lines, based on which indole- and pyrrole-fused were further evaluated by analogue preparation and in-vitro screening. Analogues with moderate to good potency were identified. This study shows the promise for further pursuit of nitrone-type small molecules in chemotherapy. [Figure not available: see fulltext.]

A shortcut hydroformylation route to 7-formyl-5,6-dihydroindolizine from 1-allyl-2-formylpyrrole

When 1-allyl-2-formylpyrrole (1) was subject to hydroformylation conditions with Rh4(CO)12 as catalyst precursor, at 100 atm total pressure and 100°C, 7-formyl-5,6-dihydroindolizine (2′) was produced together with the expected branched aldehyde (3), the linear isomer (2) being obtained in traces only. An intramolecular aldol condensation between the carbon atom adjacent to the formyl group in the chain and the carbonyl group directly bonded to pyrrole ring most likely generates the indolizine structure.

DMSO-allyl bromide: A mild and efficient reagent for atom economic one-pot: N -allylation and bromination of 2°-aryl amines, 2-aryl aminoamides, indoles and 7-aza indoles

A mixture DMSO-allyl bromide has been developed as a reagent for an atom economic one-pot N-allylation and aryl bromination under basic conditions. Utilizing this reagent, N-allylation-bromination of a number of 2°-aryl amines, aryl aminoamides, indoles, and 7-aza indoles has been achieved. The scope of the substrates and limitations, the synthetic utility of the products, and a plausible reaction mechanism have been proposed.