1010128-57-0

Basic information

• Product Name: C₂₅H₂₀N₂O₂
• Synonyms: C₂₅H₂₀N₂O₂
• CAS NO: 1010128-57-0
• Molecular Weight: 380.446
• Mol File: 1010128-57-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₀N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₀N₂O₂(1010128-57-0)
• EPA Substance Registry System: C₂₅H₂₀N₂O₂(1010128-57-0)

Safety Data

• Hazardous Substances Data: 1010128-57-0(Hazardous Substances Data)

Upstream product

• 853192-45-7 3-bromo-4-(4-methoxyphenyl)-1-methylquinolin-2(1H)-one 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 

Downstream Products

• 1010128-58-1 3-(1H-indol-2-yl)-4-(4-methoxyphenyl)-1-methylquinolin-2(1H)-one 

Relevant articles and documents

Synthesis of 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-ones via Pd-catalyzed regioselective cross-coupling reaction and cyclization

An efficient and novel route for the synthesis of 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-one 1 via palladium-catalyzed site-selective cross-coupling reaction and cyclization process was described. Reaction of 3-bromo-4-trifloxy-quinolin-2(1H)-one 3 with arylboronic acid catalyzed by PdCl2(PPh3)2 afforded 3-bromo-4-aryl-quinolin-2(1H)-one 4, which then reacted with 2-ethynylaniline 5 via Pd-catalyzed Sonogashira coupling and CuI-mediated cyclization leading to the desired 1H-indol-2-yl-(4-aryl)-quinolin-2(1H)-one 1 in good yields.