130658-14-9

Usage

Uses

Used in Organic Synthesis:
4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is used as an intermediate in organic synthesis for the preparation of various pharmaceutical and biologically active substances. Its unique structure and the presence of the tert-butyl ester group make it a valuable building block in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a key intermediate for the development of new drugs and pharmaceuticals. Its chemical properties and reactivity make it suitable for the synthesis of a wide range of biologically active compounds.
Used in Analytical Chemistry and Spectroscopy:
4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is also employed as a reference standard in analytical chemistry and spectroscopy applications. Its well-defined structure and properties make it an ideal candidate for calibration and quality control purposes in various analytical techniques.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a key building block for the synthesis of various drug candidates. Its unique structure and reactivity contribute to the development of novel therapeutic agents with potential applications in the treatment of various diseases and medical conditions.

InChI:InChI=1/C12H19NO3/c1-12(2,3)16-11(15)13-6-8-4-5-10(14)9(8)7-13/h8-9H,4-7H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 101046-32-6 (1R*,5S*)-N-benzyl-3-azabicyclo<3.3.0>octan-8-one 
• 930-30-3 cyclopent-2-enone 
• 127430-46-0 hexahydrocyclopenta[c]pyrrol-4(5H)-one hydrochloride 
• 185692-51-7 7-Benzyl-2-oxo-7-azabicyclo[3.3.0]octane 

Downstream Products

• 130658-13-8 tert-butyl (3aR,4R,6aS)-4-hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 
• 1187930-92-2 tert-butyl 4-amino-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate 
• 130658-13-8 tert-butyl 4-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres

This Letter describes the development and SAR of a novel series of GlyT1 inhibitors derived from a scaffold hopping approach, in lieu of an HTS campaign, which provided intellectual property position. Members within this new [3.3.0]-based series displayed excellent GlyT1 potency, selectivity, free fraction, and modest CNS penetration. Moreover, enantioselective GlyT1 inhibition was observed, within this novel series and a number of other piperidine bioisosteric cores.

3.3.0 BICYCLIC GLYT1 INHIBITORS AND METHODS OF MAKING AND USING SAME

In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GIyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GIyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

TRICYCLIC HETEROARYL PIPERAZINES, PYRROLIDINES AND AZETIDINES AS SEROTONIN RECEPTOR MODULATORS

The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydro

Azabicyclic compounds are central nervous system active agents

Compounds of formula (I) are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system.