101067-70-3

Basic information

• Product Name: N-[(3S,4R)-1-(2-Hydroxy-2-phenyl-ethyl)-2-oxo-4-phenyl-azetidin-3-yl]-2-phenoxy-acetamide
• Synonyms: N-[(3S,4R)-1-(2-Hydroxy-2-phenyl-ethyl)-2-oxo-4-phenyl-azetidin-3-yl]-2-phenoxy-acetamide
• CAS NO: 101067-70-3
• Molecular Weight: 416.477
• Mol File: 101067-70-3.mol

Chemical Properties

• CAS DataBase Reference: N-[(3S,4R)-1-(2-Hydroxy-2-phenyl-ethyl)-2-oxo-4-phenyl-azetidin-3-yl]-2-phenoxy-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(3S,4R)-1-(2-Hydroxy-2-phenyl-ethyl)-2-oxo-4-phenyl-azetidin-3-yl]-2-phenoxy-acetamide(101067-70-3)
• EPA Substance Registry System: N-[(3S,4R)-1-(2-Hydroxy-2-phenyl-ethyl)-2-oxo-4-phenyl-azetidin-3-yl]-2-phenoxy-acetamide(101067-70-3)

Safety Data

• Hazardous Substances Data: 101067-70-3(Hazardous Substances Data)

Upstream product

• 101067-68-9 (3S,4R)-3-Amino-1-(2-hydroxy-2-phenyl-ethyl)-4-phenyl-azetidin-2-one 
• 701-99-5 Phenoxyacetyl chloride 
• 14231-45-9 N-(phenoxy-acetyl)glycine 
• 102488-29-9 [1-Phenyl-meth-(E)-ylidene]-(2-phenyl-2-trimethylsilanyloxy-ethyl)-amine 
• 101067-64-5 [1-Phenyl-meth-(Z)-ylidene]-(2-phenyl-2-trimethylsilanyloxy-ethyl)-amine 

Downstream Products

• 71703-48-5 cis-3-Phenoxyacetylamino-4-phenyl-2-azetidinone 
• 101067-74-7 N-[(3R,4S)-2-Oxo-4-phenyl-1-((E)-styryl)-azetidin-3-yl]-2-phenoxy-acetamide 
• 114497-99-3 cis-1-benzoylmethyl-3-phenoxyacetamido-4-phenylazetidin-2-one 
• 101067-72-5 N-[(3S,4R)-1-(2-Bromo-2-phenyl-ethyl)-2-oxo-4-phenyl-azetidin-3-yl]-2-phenoxy-acetamide 

Relevant articles and documents

PYRIDINE ASSISTED OXIDATIONS OF ALCOHOLS TO CARBONYL COMPOUNDS BY MEANS OF 3-CARBOXYPYRIDINIUM DICHROMATE (NDC) REAGENT.

3-carboxypyridinium dichromate (NDC), readly prepareted from nicotinic acid and chromium trioxide, is an efficient reagent for the oxidation of alcohols into carbonyl compounds in the presence of pyridine.The optimum molar ratio substrate:reagent:pyridine to ensure complete oxidation of starting material in a short reaction time was found 1:2.5:20 respectlively.A brief compouison between this reagent and pyridinium dichromate (PDC) is made.In contrast to the PDC reagent, NDC allows selective oxidation between benzylic alcohols and aliphatic alcohols.The NDC-pyridine system has been successfully extended to the oxidation of N-(2-hidroxy-2-phenyl or 2-methylethyl)-β-lactams into their corresponding carbonyl compounds as N-H azetidin-2-one precursor.In contrast, primary N-(2-hydroxyethyl)-β-lactams upon treatment with this reagent system afforded N-formylazetidin-2-ones.The influence of pyridine in oxidations by means of NDC is further shown in the conversion of hydroquinones into quinones.Another interesting feature associated with the use of this reagent is the ease of purification of the final products.

A NOVEL SYNTHETIC APPROACH TO N-UNSUBSTITUTED β-LACTAMS

A convenient simple route to N-unsubstituted β-lactams is described.Formation of unusual N-styryl-β-lactams is the key of the method.