1011291-01-2Relevant academic research and scientific papers
New methods for the synthesis of 2-aminothiazolones
Caille, Seb,Bercot, Eric A.,Cui, Sheng,Faul, Margaret M.
, p. 2003 - 2006 (2008/09/20)
(Chemical Equation Presented) Two new methods for the synthesis of 2-aminothiazolones from 2-(4-methoxybenzylthio)acetic acids are described. A single reagent and simple experimental conditions are used in the key tandem deprotection-cyclization process. In the first approach 2-aminothiazolones are directly accessed via cyclization of the corresponding N-acylisothioureas. The second complementary approach provides access to a variety of 2-thiomethylthiazolones via cyclization of N-acyldithioimidates. The product 2-thiomethylthiazolones are then efficiently converted to 2-aminothiazolones via amine displacement.
