136847-16-0Relevant academic research and scientific papers
Zn complex of diaminedithiol tetradentate ligand as a stable precursor for 99mTc-labeled compounds
Arano, Yasushi,Hino, Akihiro,Koike-Satake, Miho,Oshikiri, Shinobu,Suzuki, Hiroyuki,Uehara, Tomoya
, (2020)
The diaminedithiol (N2S2) tetradentate ligand constitutes a useful chelating molecule for preparing 99mTc-labeled compounds of high in vivo stability in high radiochemical yields. However, since the thiol groups in the N2S2 ligand are easy to be oxidized to disulfide bonds, they need to be protected with an appropriate protecting group, which hinders the broad applications of the N2S2 ligand for radiopharmaceuticals. In this study, a Zn chelate of N2S2 was evaluated as a precursor for purification-free 99mTc-labeled N2S2 under the mild and simple procedure. Zn-N2S2 was prepared by reacting Zn acetate with N2S2, and the Zn-N2S2 remained stable under aerobic conditions at room temperature. 99mTc-N2S2 was obtained over 90% radiochemical yields at room temperature by a one-pot reaction, consisting of Zn-N2S2 (10?5 M), 99mTcO4?, ethylenediaminetetraacetic acid (EDTA), and a reducing agent (Sn2+) at pH = 5.5 to 7.5. 99mTc-N2S2 was also obtained over 90% radiochemical yields when the reaction was conducted in the presence of an equimolar amount of IgG antibody. These findings indicate the Zn complex of N2S2 ligand constitutes a stable and useful precursor to prepare 99mTc-labeled N2S2 compounds in high yields under the mild and simple procedure.
Method for the preparation of 3-benzylthio-2-alkylpropionic acid and its derivatives
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, (2008/06/13)
A method is provided for the preparation of derivative of 3-benzylthio-2-alkylpropionic acid of formula (I): STR1 wherein X is independently selected from hydrogen, C1 -C6 alkyl or C1 -C6 alkoxyl, and R is indep
Diagnostic radiopharmaceutical compounds (That)
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, (2008/06/13)
Tetradentate ligands are used to form neutral 99m-technetium complexes which may be useful as radiopharmaceuticals e.g. as brain imaging agents. The ligands have the structure STR1 where n is 2 or 3, m is 0-4, R is H or substituted or unsubstituted C1 -C6 alkyl, provided that one CR2 group adjacent the starred nitrogen atom represents CO and forms with the adjacent N atom, a --CONH-- amide group, Y is unsubstituted or substituted C1 -C6 alkyl, and one of X and X' represents H or a labile thiol protecting group while the other is unsubstituted or substituted C1 -C6 alkyl, alkenyl or alkynyl.
Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
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, (2008/06/13)
The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula STR1 useful as inhibitors of enkephalinase.
2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
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, (2008/06/13)
The present invention relates to novel 2-substitited indane-2-mercaptoacetylamide tricyclic derivatives which are useful as inhibitors of Enkephalise.
Synthesis of thiazolidine-2-thione derivatives and evaluation of their hepatoprotective effects
Yoneda,Ota,Kawashima
, p. 876 - 881 (2007/10/02)
A series of N-(mercaptoalkyl)thiazolidine-2-thiones and their derivatives were synthesized and evaluated for hepatoprotective activities against Propionibacterium acnes-lipopolysaccharide (R. acnes-LPS)-induced liver injury in mice and in vitro lipid pero
New conformationally restricted 99mTc N2S2 complexes as myocardial perfusion imaging agents
Ohmomo,Francesconi,Kung,Kung
, p. 157 - 162 (2007/10/02)
In developing 99mTc complexes as potential myocardial imaging agents, a new series of ligands based on a conformationally restricted N2S2 system were investigated. Using piperazine or homopiperazine as the starting materia
