10113-35-6

Basic information

• Product Name: 2',6'-Dichloroformanilide
• Synonyms: 2',6'-Dichloroformanilide;N-(2,6-Dichlorophenyl)formamide
• CAS NO: 10113-35-6
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.03
• Mol File: 10113-35-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 175-178 °C
• Boiling Point: 356°C at 760 mmHg
• Flash Point: 169.1°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 3E-05mmHg at 25°C
• Refractive Index: 1.622
• PKA: 13.14±0.70(Predicted)
• CAS DataBase Reference: 2',6'-Dichloroformanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2',6'-Dichloroformanilide(10113-35-6)
• EPA Substance Registry System: 2',6'-Dichloroformanilide(10113-35-6)

Safety Data

• Hazardous Substances Data: 10113-35-6(Hazardous Substances Data)

Usage

General Description

2',6'-Dichloroformanilide is a chemical compound with the molecular formula C7H6Cl2NO. It is a white solid that is sparingly soluble in water and commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2',6'-Dichloroformanilide is also used as an intermediate in the production of dyes, pigments, and other organic compounds. It is known to be a skin and eye irritant and should be handled with care. Additionally, 2',6'-Dichloroformanilide may be harmful if inhaled or ingested and should be stored and used in a well-ventilated area with appropriate personal protective equipment.

InChI:InChI=1/C7H5Cl2NO/c8-5-2-1-3-6(9)7(5)10-4-11/h1-4H,(H,10,11)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 608-31-1 2,6-Dichloroaniline 
• 15307-79-6 diclofenac sodium 
• 10535-67-8 trimethylacetic formic anhydride 
• 64-18-6 formic acid 

Downstream Products

• 6697-95-6 1,3-dichloro-2-isocyanobenzene 
• 21709-18-2 N-(2,6-dichlorophenyl)-1,1-dichloromethanimine 
• 4205-90-7 Clonidin 
• 4205-91-8 clonidine hydrochloride 
• 101003-41-2 cis-3-(2,6-dichlorophenyl)-5-methyl-1,2,3-oxathiazolidine-2-oxide 
• 101003-41-2 trans-3-(2,6-dichlorophenyl)-5-methyl-1,2,3-oxathiazolidine-2-oxide 
• 83843-26-9 1-(2,6-dichlorophenyl-amino)-2-methanesulfonyloxy-propane 
• 83842-87-9 N²-(2,6-Dichloro-phenyl)-N¹,N¹-dimethyl-propane-1,2-diamine 
• 110891-57-1 1-(2,6-Dichloro-phenylamino)-propan-2-ol 
• 77486-35-2 N'-(2,6-Dichloro-phenyl)-N,N-dipropyl-formamidine 

Relevant articles and documents

A preparation method of the clonidine hydrochloride

The invention discloses a method for preparing the clonidine hydrochloride, including intermediates 1 synthesis, intermediate 2 synthesis and clonidine hydrochloride synthetic three steps, the present invention in order to 2, 6 - dichloroaniline as raw materials, through the hydroformylation reaction get intermediate 1, "one-pot" get clonidine free base, finally with hydrogen chloride ethanol solution into salt clonidine hydrochloride. By processing the raw material synthetic process, by utilizing the free alkali in the course of refining into salt after adjusting pH, and the clonidine hydrochloride is used for purification of the pulping process control such as ethyl acetate, to obtain a high-purity clonidine hydrochloride preparation method. The method not only improves the product purity and yield, impurity can also effectively control, but also greatly reducing the cost, simplifying the process, is more suitable for industrial production.

Simultaneous identification of Fenton degradation by-products of diclofenac, ibuprofen and ketoprofen in aquatic media by comprehensive two-dimensional gas chromatography coupled with mass spectrometry

Diclofenac, ibuprofen and ketoprofen are anti-inflammatory drugs intensively used both in human and animal treatment. Due to their high stability these compounds are partially removed by wastewater treatment plants and from this reason the development of some alternative treatments such as advanced oxidative processes are necessary. The main problems in the optimization of an advanced oxidative process rise from the difficulties which appear in the identification of degradation by-products necessary for the establishment of degradation pathway. In this paper a developed method for the simultaneous identification of Fenton degradation by-products of the three above mentioned pharmaceuticals is presented. The obtained results show the comprehensive two-dimensional gas chromatography coupled with mass spectrometry as a proper method for the analysis of the complex mixture of compounds resulted from the Fenton degradation process. Moreover, some compounds never mentioned in the scientific literature were identified. (Chemical Equation Presented).

Screw Sense Selective Polymerization of Achiral Isocyanides Catalysed by Optically Active Nickel(II) Complexes

Poly(isocyanides), (RN=Cn, can be prepared from isocyanides, , by the catalytic action of nickel(II) compounds.The main chain of these polymers is a rigid helix.This helical conformation results from a restricted rotation around the single bonds that connect the main-chain carbon atoms.Polymerization of achiral isocyanides generally gives a racemic mixture of left- and right-handed helices, whereas polymerization of optically active isocyanides results in helices with an excess of one screw sense.We describe a procedure for obtaining poly(isocyanides) with predominantly one screw sense, starting from an achiral monomer.A catalyst is prepared by adding an optically active amine to a tetrakis(isocyanide)nickel(II) perchlorate complex.Polymerization of various achiral isocyanides with this catalist yields optically active polymers with an enantiomeric excess up to 83percent.