1011416-46-8

Basic information

• Product Name: (3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-acetic acid methyl ester
• Synonyms: (3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-acetic acid methyl ester
• CAS NO: 1011416-46-8
• Molecular Weight: 246.266
• Mol File: 1011416-46-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-acetic acid methyl ester(1011416-46-8)
• EPA Substance Registry System: (3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-acetic acid methyl ester(1011416-46-8)

Safety Data

• Hazardous Substances Data: 1011416-46-8(Hazardous Substances Data)

Usage

General Description

The chemical (3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-acetic acid methyl ester is a compound with the molecular formula C12H13N2O3. It belongs to the class of organic compounds known as pyrazoles. This chemical is a methyl ester derivative of (3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)-acetic acid and is commonly used in medicinal and pharmaceutical research for its potential biological activities. However, due to its specific structure and properties, it is important to handle this chemical with caution and use it in accordance with safety guidelines.

Upstream product

• 10420-33-4 dimethyl 2-acetylsuccinate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1189155-54-1 (5-methoxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-acetic acid methyl ester 
• 111526-25-1 (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-acetic acid methyl ester 
• 1401340-62-2 4-(cyanomethyl)-4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazole-4-acetic acid methyl ester 
• 1401340-75-7 2-(cyanomethyl)-3-methyl-5-oxo-1-phenyl-3-pyrazoline-4-acetic acid methyl ester 
• 1005750-46-8 2,3-dihydro-5-methyl-3-oxo-2-phenyl-4-pyridazineacetic acid methyl ester 

Relevant articles and documents

A novel synthesis of 4-pyridazineacetic acids via ring expansion of N-cyanomethylated 3-pyrazoline-4-acetic acids

A novel synthetic route to 4-pyridazineacetic acids 10-12 has been achieved by the ring-expansion reaction of N-cyanomethylated 3-pyrazoline-4-acetic acids 7-9. 1H-Pyrazole-4-acetic acids 1-3 were reacted with iodoacetonitrile in the presence of triethylamine in refluxing acetonitrile to give the corresponding C-cyanomethylated 1H-pyrazole-4-acetic acids 4-6 as major products together with N-cyanomethylated 3-pyrazoline-4-acetic acids 7 and 8 as minor products. On the other hand, reactions of 1 and 3 with chloroacetonitrile in the presence of triethylamine in refluxing chloroform afforded the corresponding N-cyanomethylated 3-pyrazoline-4-acetic acids 7 and 9 as major products. Thermal treatment of 7-9 with sodium hydride in N,N-dimethylformamide caused ring expansion to yield the corresponding 4-pyridazineacetic acids 10-12.