1011465-24-9

Basic information

• Product Name: R-3,3'-bis((3,5-bis(trifluoroMethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate
• Synonyms: R-3,3'-bis((3,5-bis(trifluoroMethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate;(R)-3,3'-Bis[3,5-bis(trifluoromethyl)phenyl]- 5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diyl Hydrogen Phosphate,99%e.e.;(11bR)-2,6-Bis[3,5-bis(trifluoromethyl)phenyl]-8,9,10,11,12,13,14,15-octahydro-4-hydroxy-4-oxide-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin
• CAS NO: 1011465-24-9
• Molecular Formula: C36H25F12O4P
• Molecular Weight: 780.5358994
• Mol File: 1011465-24-9.mol

Chemical Properties

• Melting Point: 167-169 °C
• Boiling Point: 714.4±70.0 °C(Predicted)
• Appearance: white to light-yellow/Powder
• Density: 1.57±0.1 g/cm3(Predicted)
• PKA: 1.09±0.20(Predicted)
• CAS DataBase Reference: R-3,3'-bis((3,5-bis(trifluoroMethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate(CAS DataBase Reference)
• NIST Chemistry Reference: R-3,3'-bis((3,5-bis(trifluoroMethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate(1011465-24-9)
• EPA Substance Registry System: R-3,3'-bis((3,5-bis(trifluoroMethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate(1011465-24-9)

Safety Data

• Hazardous Substances Data: 1011465-24-9(Hazardous Substances Data)

Upstream product

• 1228600-99-4 (R)-3,3'-bis-(3,5-bis-trifluoromethylphenyl)-5,6,7,8,5',6',7',8'-octahydro-[1,1']binaphthalenyl-2,2'-diol 

Relevant articles and documents

31P NMR Based Method for Determining Enantiopurity of Chiral Phosphoric Acids and Its Application to the BINOL- and H8-BINOL-Based Chiral Phosphoric Acid Thermal Racemization Studies

A simple and reliable protocol for determining the enantiopurity of 3,3′-substituted BINOL- and H8-BINOL-based chiral phosphoric acids (CPA) using 31P NMR spectroscopy in the presence of chiral amines as the discriminating agents is described.

Direct Interconversion of BINOL and H8-BINOL-Based Chiral Br?nsted Acids Using Single-Step Red/Ox Manipulations

A direct single-step hydrogenation of BINOL-based chiral phosphoric acids, N-triflyl phosphoramides, and disulfonimides to the corresponding H8-BINOL Br?nsted acids in excellent yields and chemoselectivities is described. In addition, the conditions for t

Chiral phosphoric acid catalyzed asymmetric friedel-crafts alkylation of indoles with nitroolefins

Asymmetric Michael-type Friedel-Crafts (F-C) alkylations of indoles with nitroolefins catalyzed by a chiral H8-BINOL-based phosphoric acid were investigated. The reactions took place very smoothly in the presence of only 5 mol-% of catalyst at

A convenient protocol for the synthesis of axially chiral Br?nsted acids

Partially hydrogenated binaphthol monophosphoric acids were prepared via an improved four-step sequence. It is demonstrated that typical protection and deprotection of the phenolic groups are dispensable. The vinyl-substituted derivative has been polymerized to give a novel polymerized organocatalyst.

Enantioselective BINOL-phosphoric acid catalyzed Pictet - Spengler reactions of N-benzyltryptamine

(Chemical Equation Presented) Optically active tetrahydro-β-carbolines were synthesized via an (R)-BINOL-phosphoric acid-catalyzed asymmetric Pictet-Spengler reaction of N-benzyltryptamine with a series of aromatic and aliphatic aldehydes. The tetrahydro-β-carbolines were obtained in yields ranging from 77% to 97% and with ee values up to 87%. The triphenylsilyl- substituted BINOL-phosphoric acid proved to be the catalyst of choice for the reaction with aromatic aldehydes. For the aliphatic aldehydes, 3,5-bistrifluoromethylphenyl-substituted BINOL-phosphoric acid was identified as the best catalyst.

Chiral phosphoric acid catalyzed asymmetric Friedel-Crafts alkylation of indoles with simple α,β-unsaturated aromatic ketones

Asymmetric Michael-type Friedel-Crafts (F-C) alkylations of indoles with nonchelating α,β-unsaturated aromatic ketones catalyzed by a chiral H8-BINOL-based phosphoric acid were investigated. The reactions took place smoothly in the presence of