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S-3,3'-bis(3,5-bis(trifluoroMethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2,2'-naphthol, commonly known as bisphenol A (BPA), is a synthetic organic compound that is extensively utilized in the manufacturing of polycarbonate plastics and epoxy resins. S-3,3'-bis(3,5-bis(trifluoroMethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2,2'-naphthol is a vital component in a multitude of consumer products, including food and beverage containers, baby bottles, and dental sealants. However, BPA has garnered attention due to its potential estrogenic activity, which raises concerns about its possible negative impacts on human health, especially in relation to hormonal and reproductive systems. Studies have associated BPA exposure with a range of health issues, such as infertility, obesity, and cancer, prompting a push towards finding safer alternatives for use in consumer products.

1228600-99-4

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1228600-99-4 Usage

Uses

Used in Plastics Industry:
BPA serves as a crucial raw material in the production of polycarbonate plastics, which are known for their durability and transparency. These plastics are used in a variety of applications, including the manufacturing of compact discs, DVDs, eyeglass lenses, and protective gear.
Used in Epoxy Resin Production:
In the coatings industry, BPA is used to produce epoxy resins, which are valued for their adhesive properties and chemical resistance. These resins are commonly employed in the coating of metal products, such as food cans, and in the production of electrical insulation systems.
Used in Dental Sealants:
BPA is also a component of dental sealants, which are applied to the chewing surfaces of teeth to protect against tooth decay. S-3,3'-bis(3,5-bis(trifluoroMethyl)phenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2,2'-naphthol's properties make it suitable for this application, as it helps in forming a hard, protective barrier.
However, due to the health concerns associated with BPA, there is a growing trend towards the development and use of alternative materials that do not possess the potential risks linked to BPA. This shift is evident across various industries as manufacturers and consumers alike seek safer options for everyday products.

Check Digit Verification of cas no

The CAS Registry Mumber 1228600-99-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,6,0 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1228600-99:
(9*1)+(8*2)+(7*2)+(6*8)+(5*6)+(4*0)+(3*0)+(2*9)+(1*9)=144
144 % 10 = 4
So 1228600-99-4 is a valid CAS Registry Number.

1228600-99-4Downstream Products

1228600-99-4Relevant academic research and scientific papers

The development of the asymmetric Morita-Baylis-Hillman reaction catalyzed by chiral Bronsted acids

McDougal, Nolan T.,Trevellini, Whitney L.,Rodgen, Stacy A.,Kliman, Laura T.,Schaus, Scott E.

, p. 1231 - 1240 (2004)

This report describes the development of a chiral Bronsted acid-catalyzed asymmetric Morita-Baylis-Hillman (MBH) reaction of cyclohexenone with aldehydes. During the course of our studies on chiral Lewis acid-promoted MBH reactions, we discovered that chi

Novel phosphoramidite ligand, preparation method thereof and application thereof in asymmetric carbonylation reaction

-

Paragraph 0044-0047; 0052-0055, (2021/09/29)

I Application of the asymmetric II carbonylating reaction strategy, and the synthetic problems of the hexahydropyrrolindole alkaloid and the dimeric cyclic amine alkaloid are effectively solved by using the monodentate chiral ligand to solve the problem of low enantioselectivity in the asymmetric domino Heck Heck and carbonylation reaction.

Synthesis and structural aspects of N-triflylphosphoramides and their calcium salts'highly acidic and effective Bronsted acids

Rueping, Magnus,Nachtsheim, Boris J.,Koenigs, Rene M.,Ieawsuwan, Winai

experimental part, p. 13116 - 13126 (2011/02/24)

Recently, 1,1′-bi-2-naphthol (BINOL)-based N-triflylphosphoramides emerged as a new class of potent Bronsted acid catalysts. In this paper we describe the efficient synthesis of various BINOL-based N- triflylphosphoramides and their calcium salts. Furthermore, X-ray crystal structure analysis combined with energy-dispersive X-ray spectroscopy (EDX) measurements confirmed that the synthesised chiral N-triflylphosphoramides are highly acidic metal-free catalysts. Freedom! The synthesis and structure determination of various 1,1′-bi-2-naphthol (BINOL)-based N-triflylphosphoramides and their corresponding calcium salts is presented. A simple acidic treatment of the calcium salts provides the metal-free Bronsted acids (see scheme; Tf=trifluoromethanesulfonyl).

Synthesis of BINOL derived phosphorodithioic acids as new chiral Br?nsted acids and an improved synthesis of 3,3′-disubstituted H8-BINOL derivatives

Pousse, Guillaume,Devineau, Alice,Dalla, Vincent,Humphreys, Luke,Lasne, Marie-Claire,Rouden, Jacques,Blanchet, Jér?me

experimental part, p. 10617 - 10622 (2010/01/16)

Original phosphorodithioic acid diesters were prepared according to an improved synthesis of 3,3′-disubstituted H8-BINOL derivatives. In preliminary experiments, these new Br?nsted acids were tested as organocatalysts in three reactions. They promoted the Nazarov cyclisation with mixed selectivities, the Mannich reaction with good enantioselectivity and they catalyzed efficiently the alkylation of N-acyliminium with enol silyl ether.

A convenient protocol for the synthesis of axially chiral Br?nsted acids

Bartoszek, Michael,Beller, Matthias,Deutsch, Jens,Klawonn, Markus,K?ckritz, Angela,Nemati, Navid,Pews-Davtyan, Anahit

, p. 1316 - 1322 (2008/09/17)

Partially hydrogenated binaphthol monophosphoric acids were prepared via an improved four-step sequence. It is demonstrated that typical protection and deprotection of the phenolic groups are dispensable. The vinyl-substituted derivative has been polymerized to give a novel polymerized organocatalyst.

Asymmetric Morita-Baylis-Hillman reactions catalyzed by chiral Bronsted acids

McDougal, Nolan T.,Schaus, Scott E.

, p. 12094 - 12095 (2007/10/03)

Chiral BINOL-derived Bronsted acids catalyze the enantioselective asymmetric Morita-Baylis-Hillman (MBH) reaction of cyclohexenone with aldehydes. The asymmetric MBH reaction requires 2-20 mol % of the chiral Bronsted acid 2e or 2f and triethylphosphine a

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