10116-74-2

Upstream product

• 17260-71-8 3-chloro-benzenesulfonamide 
• 456-39-3 3-chlorobenzenediazonium tetrafluoroborate 
• 368-50-3 3-amino-benzenesulfonyl fluoride 
• 2888-06-4 3-chlorophenylsulfonyl chloride 

Downstream Products

• 331765-61-8 4-[4-(3-chloro-benzenesulfonyl)-benzyl]-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 
• 864872-96-8 N-(1-{4-[4-chloro-2-(3-chloro-benzenesulfonyl)-benzenesulfonyl]-phenyl}-ethyl)-2,2,2-trifluoro-acetamide 
• 331765-69-6 C₃₀H₃₉ClN₂O₆S 
• 331765-62-9 4-[4-(3-chloro-benzenesulfonyl)-benzyl]-[1,4']bipiperidinyl 
• 331765-50-5 Sch 211803 

Relevant academic research and scientific papers

Visible-Light-Mediated Synthesis of Sulfonyl Fluorides from Arylazo Sulfones

Sulfonyl fluorides are useful motifs for a wide range of applications in organic synthesis including sulfur (VI) fluoride exchange-based “click chemistry.” Herein, a visible-light-mediated synthesis of sulfonyl fluorides from arylazo sulfones is described. In the present study, K2S2O5 and N-fluorobenzenesulfonimide (NFSI) were used as the sulfonyl source and fluorinating agent, respectively, for visible-light-mediated fluorosulfonylation of arylazo sulfones to prepare various sulfonyl fluorides in 60–85% yield. This protocol is a synthetic approach to provide useful sulfonyl fluoride structures at room temperature. (Figure presented.).

Synthesis of Sulfonyl Fluorides from Sulfonamides

A simple and practical synthesis of sulfonyl fluorides from sulfonamides is reported. The method capitalizes on the formation of the sulfonyl chloride by virtue of the reaction of Pyry-BF4 and MgCl2, and subsequent in situ conversion to the more robust and stable sulfonyl fluoride by the presence of KF. The mild conditions and high chemoselectivity of the protocol enable the late-stage formation of sulfonyl fluorides from densely functionalized molecules.

ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS

This invention relates to substituted pyrrolidine compounds of the formula I wherein m, n, Ar, R1 and R2 are as defined herein. Methods of making the compounds and using the compounds are disclosed.

NOVEL COMPOUNDS

The present invention relates to novel indole derivatives such as compounds of the formula (I): which possess antagonist potency at the 5-HT6 receptor and the use of such compounds or pharmaceutically acceptable salts or solvates thereof in the treatment of Alzheimer's disease and other CNS disorders.

Muscarinic M2 antagonists: Anthranilamide derivatives with exceptional selectivity and in vivo activity

Anthranilamide analogues such as 23 are potent and highly selective muscarinic M2 antagonists that also show good oral bioavailability and in vivo activity.