1011708-22-7

Basic information

• Product Name: methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester
• Synonyms: methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester
• CAS NO: 1011708-22-7
• Molecular Weight: 430.223
• Mol File: 1011708-22-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester(1011708-22-7)
• EPA Substance Registry System: methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester(1011708-22-7)

Safety Data

• Hazardous Substances Data: 1011708-22-7(Hazardous Substances Data)

Upstream product

• 950998-60-4 tert-butyl 2-(bis(2-(methylsulfonyloxy)ethyl)amino)-3,5-dinitrobenzoate 
• 950998-61-5 tert-butyl 2-((2-bromoethyl)-(2-((methylsulfonyl)oxy)ethyl)amino)-3,5-dinitrobenzoate 
• 950998-59-1 tert-butyl 2-(bis(2-hydroxyethyl)amino)-3,5-dinitrobenzoate 
• 87363-66-4 tert-butyl 2-chloro-3,5-dinitrobenzoate 
• 944088-85-1 tert-butyl 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoate 
• 944088-72-6 tert-butyl 2-[(2-hydroxyethyl)(2-chloroethyl)amino]-3,5-dinitrobenzoate 
• 944088-89-5 2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoic acid 
• 950998-62-6 2-((2-bromoethyl)-(2-((methylsulfonyl)oxy)ethyl)amino)-3,5-dinitrobenzoic acid 

Downstream Products

• 851627-43-5 2-[(2-chloroethyl)-2-[[(2-hydroxyethyl)amino]carbonyl]-4,6-dinitroanilino]ethyl methanesulfonate 

Relevant articles and documents

PROCESSES OF PREPARING ASYMMETRIC DINITROBENZAMIDE MUSTARD COMPOUNDS, INTERMEDIATE COMPOUNDS USEFUL THEREIN AND PRODUCTS OBTAINED THEREFROM

The invention relates to methods of preparing compounds of formula (II) wherein Z represents -OR1 or -N(R2)R2a-, where R1 is lower alkylene (C1-C6), R2 is lower alkyl or H and R

Synthesis of asymmetric halomesylate mustards with aziridineethanol/alkali metal halides: application to an improved synthesis of the hypoxia prodrug PR-104

Aromatic asymmetric halomesylate mustards are efficiently prepared by reaction of activated aromatic chlorides with aziridineethanol/alkali metal halides, followed by mesylation of the haloalcohol. The reaction conditions are sufficiently mild to be compatible with a range of different substituents and protecting groups, including carboxylate and phosphate esters, and have been used in an improved synthesis of the anticancer bromomesylate mustard PR-104, now in clinical trials.