methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester

Base Information

Chemical Name:methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester
CAS No.:1011708-22-7
Molecular Formula:C₁₂H₁₃Cl₂N₃O₈S
Molecular Weight:430.223
Hs Code.:

Synonyms:methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester

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Technology Process of methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester

There total 8 articles about methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944088-89-5
2-[(2-chloroethyl)[2-[(methylsulfonyl)oxy]ethyl]amino]-3,5-dinitrobenzoic acid

: 1011708-22-7
methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1016/j.tet.2007.04.044

Reference yield:

: 950998-62-6
2-((2-bromoethyl)-(2-((methylsulfonyl)oxy)ethyl)amino)-3,5-dinitrobenzoic acid

: 1011708-22-7
methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester

: methanesulfonic acid 2-[(2-bromo-ethyl)-(2-chlorocarbonyl-4,6-dinitro-phenyl)-amino]-ethyl ester

Guidance literature:: With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1002/jlcr.1147

Reference yield:

: 87363-66-4
tert-butyl 2-chloro-3,5-dinitrobenzoate

: 1011708-22-7
methanesulfonic acid 2-[(2-chlorocarbonyl-4,6-dinitro-phenyl)-(2-chloro-ethyl)-amino]-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / LiCl / dimethylformamide / cooling

2: 89 percent / Et₃N / CH₂Cl₂ / 0 °C

3: 88 percent / TFA / 2 h / 20 °C

4: (COCl)2; DMF / CH₂Cl₂ / 1.5 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.04.044