1012-92-6

Basic information

• Product Name: 1-(2,6-dimethylphenyl)piperazine hydrochloride
• Synonyms: 1-(2,6-dimethylphenyl)piperazine hydrochloride
• CAS NO: 1012-92-6
• Molecular Weight: 226.749
• Mol File: 1012-92-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2,6-dimethylphenyl)piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-dimethylphenyl)piperazine hydrochloride(1012-92-6)
• EPA Substance Registry System: 1-(2,6-dimethylphenyl)piperazine hydrochloride(1012-92-6)

Safety Data

• Hazardous Substances Data: 1012-92-6(Hazardous Substances Data)

Usage

General Description

1-(2,6-dimethylphenyl)piperazine hydrochloride is a chemical compound that belongs to the class of piperazines and is often used as an intermediate in the synthesis of pharmaceuticals. It is a salt form of the piperazine derivative, and the hydrochloride salt form enhances its solubility in water, making it suitable for use in pharmaceutical formulations. 1-(2,6-dimethylphenyl)piperazine hydrochloride has been studied for its potential therapeutic effects on various conditions, including neurological and psychiatric disorders, and has shown promise in preclinical research. It is important to handle this compound with care due to its potential health hazards and to follow proper safety protocols during its handling and storage.

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 87-62-7 2,6-dimethylaniline 

Downstream Products

• 95355-99-0 6-<2-<4-(2,6-dimethylphenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 95356-00-6 6-<2-<4-(2,6-dimethylphenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine difumarate 
• 1012-91-5 1-(2,6-dimethylphenyl)-piperazine 

Relevant articles and documents

Design, synthesis, and systematic evaluation of 4-arylpiperazine- and 4-benzylpiperidine napthyl ethers as inhibitors of monoamine neurotransmitters reuptake

Two series of 4-arylpiperazine- and 4-benzylpiperidine naphthyl ethers were designed based on structure-activity relationship (SAR) and docking model of reported monoamine neurotransmitters reuptake inhibitors. The compounds were synthesized in 3-simple steps and their biological activities were evaluated. Several compounds were proven to be potent inhibitors of serotonin and norepinephrine reuptake. Computer docking was performed to study the interaction of the most potent compound 35 with human serotonin transporter. The results of the analyses suggest that 4-arylpiperazine- and 4-benzylpiperidine naphthyl ethers might be promising antidepressants worthy of further studies.

Exploration of substituted arylpiperazine–tetrazoles as promising dual norepinephrine and dopamine reuptake inhibitors

In the search for potent dual norepinephrine and dopamine reuptake inhibitors, several substituted arylpiperazine–tetrazoles were designed, synthesized and evaluated for their neurotransmitter reuptake inhibitory activities. Various derivatives exhibited selective and strong neurotransmitter reuptake inhibitory activity. In particular, compounds with a three-carbon linker displayed selective and stronger potency than those with two-carbon and four-carbon linkers. Interestingly, six compounds, 9b, 9c, 9d, 9o, 9q and 9u displayed more effective activity than the standard drug, bupropion. The provided SAR data and potent biological activity can offer useful guidelines for designing dual norepinephrine and dopamine reuptake inhibitors as effective therapeutic agents for treatment of several central nervous system diseases.