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1012-91-5

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1012-91-5 Usage

General Description

1-(2,6-dimethylphenyl)piperazine is a chemical compound with the molecular formula C12H18N2. It is a piperazine derivative that is commonly used in the field of medicinal chemistry and pharmaceutical research. 1-(2,6-DIMETHYLPHENYL)PIPERAZINE has been studied for its potential pharmacological effects, particularly as a potential psychoactive drug. It has been found to have an affinity for serotonin and dopamine receptors, leading to its potential use in the treatment of various neurological disorders. Additionally, 1-(2,6-dimethylphenyl)piperazine has also been studied for its potential use as a precursor in the synthesis of other pharmaceutical compounds. Its diverse pharmacological properties make it a valuable compound for further research and development in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 1012-91-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1012-91:
(6*1)+(5*0)+(4*1)+(3*2)+(2*9)+(1*1)=35
35 % 10 = 5
So 1012-91-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2/c1-10-4-3-5-11(2)12(10)14-8-6-13-7-9-14/h3-5,13H,6-9H2,1-2H3

1012-91-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2,6-Dimethylphenyl)piperazine

1.2 Other means of identification

Product number -
Other names 2,6-dimethylphenylpiperazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1012-91-5 SDS

1012-91-5Relevant articles and documents

Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin

Bassetto, Marcella,Brancale, Andrea,Pasqualetto, Gaia,Pileggi, Elisa,Rozanowska, Malgorzata,Schepelmann, Martin,Varricchio, Carmine

supporting information, (2021/09/24)

Inherited blinding diseases retinitis pigmentosa (RP) and a subset of Leber's congenital amaurosis (LCA) are caused by the misfolding and mistrafficking of rhodopsin molecules, which aggregate and accumulate in the endoplasmic reticulum (ER), leading to photoreceptor cell death. One potential therapeutic strategy to prevent the loss of photoreceptors in these conditions is to identify opsin-binding compounds that act as chemical chaperones for opsin, aiding its proper folding and trafficking to the outer cell membrane. Aiming to identify novel compounds with such effect, a rational ligand-based approach was applied to the structure of the visual pigment chromophore, 11-cis-retinal, and its locked analogue 11-cis-6mr-retinal. Following molecular docking studies on the main chromophore binding site of rhodopsin, 49 novel compounds were synthesized according to optimized one-to seven-step synthetic routes. These agents were evaluated for their ability to compete for the chromophore binding site of opsin, and their capacity to increase the trafficking of the P23H opsin mutant from the ER to the cell membrane. Different new molecules displayed an effect in at least one assay, acting either as chemical chaperones or as stabilizers of the 9-cis-retinal-rhodopsin complex. These compounds could provide the basis to develop novel therapeutics for RP and LCA.

Pd-Catalyzed Synthesis of Piperazine Scaffolds under Aerobic and Solvent-Free Conditions

Reilly, Sean W.,Mach, Robert H.

supporting information, p. 5272 - 5275 (2016/10/31)

A facile Pd-catalyzed methodology providing an efficient synthetic route to biologically relevant arylpiperazines under aerobic conditions is reported. Electron donating and sterically hindered aryl chlorides were aminated to afford yields up to 97%, with examples using piperazine as solvent, illustrating an ecofriendly, cost-effective synthesis of these privileged structures.

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