101212-41-3

Upstream product

• 112996-01-7 5-methoxy-3,6-dimethyl-3-formylmethylphthalide 
• 74-88-4 methyl iodide 
• 82045-52-1 1-<2-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-5-methoxy-4-methylphenyl>ethanone 
• 101212-39-9 5-methoxy-3,6-dimethyl-3-(prop-2'-enyl)phthalide 
• 59931-48-5 4-methoxy-3-methylbenzoyl chloride 
• 6880-04-2 4-methoxy-3-methylbenzoic acid 

Downstream Products

• 101212-40-2 methyl 2-<(E)-1-formylprop-2-en-2-yl>-4-methoxy-5-methylbenzoate 
• 82045-56-5 methyl 2-<(6R)-10-(10-hydroxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6,8-dimethyldecan-2,4,8-trien-2-yl>-4-methoxy-5-methylbenzoate 
• 101212-46-8 2-{(1E,7E)-(R)-4-Benzenesulfonyl-3-benzoyloxy-9-[(2R,4S,6R,8R,9S)-4-(tert-butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,7-dienyl}-4-methoxy-5-methyl-benzoic acid methyl ester 

Relevant academic research and scientific papers

Total Synthesis of (+)-Milbemycin β3

The total synthesis of (+)-milbemycin β3 has been achieved in two ways beginning from the appropriate spiroacetal moiety.In the first, coupling of a vinyl-lithium derivative (18) with the spiroacetal aldehyde (19), available from Swern oxidatio

The Total Synthesis of (+)-Milbemycin β3

We report the total synthesis of (+)-milbemycin β3 from the optically pure precursors spiroacetal (3) and vinyl iodide (2), and the aromatic aldehyde (4).