82045-56-5

Upstream product

• 82467-25-2 (+)-(5S,6R)-tetrahydro-5,6-dimethyl-2H-pyran-2-one 
• 101906-15-4 (3S)-1-benzyloxy-5-methylhex-5-en-3-ol 
• 114180-38-0 (2R,6R,8R,9S)-2-(2-hydroxyethyl)-8,9-dimethyl-1,7-dioxaspiro<5.5>undecan-4-one 
• 114092-29-4 (2R,4S,6R,8R,9S)-4-(dimethyl-t-butylsiloxy)-2-(2-hydroxyethyl)-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 114092-28-3 Acetic acid 2-[(2R,4S,6R,8R,9S)-4-(tert-butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-ethyl ester 
• 101212-47-9 methyl 2-<(6'R)-(10-diphenyl-t-butylsiloxy-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan-8-yl)-6',8'-dimethyldecan-2',4',8'-trien-2'-yl>-4-methoxy-5-methylbenzoate 
• 82045-55-4 2-{(1E,3E,7E)-(S)-9-[(2S,4R,6S,8S,9R)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,3,7-trienyl}-4-methoxy-5-methyl-benzoic acid methyl ester 
• 82045-37-2 2-<3-(diphenylphosphinyl)-1-propenyl>-4-methoxy-5-methyl-(E)-benzoic acid 
• 82045-55-4 2-{(1E,3E,7E)-(R)-9-[(2S,4R,6S,8S,9R)-4-(tert-Butyl-dimethyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-1,5,7-trimethyl-nona-1,3,7-trienyl}-4-methoxy-5-methyl-benzoic acid methyl ester 
• 101906-21-2 (2R,4R,6S,8R,9S)-2-<(5R)-(2E)-6-benzyloxy-3,5-dimethyl-hex-2-en-1-yl>-8,9-dimethyl-4-(dimethyl-t-butylsilyloxy)-1,7-dioxaspiro<5.5>undecane 
• 82045-36-1 (2S,4S,6S,8R,9S)-4-(dimethyl-t-butylsiloxy)-2-<(5R,2E)-5-formyl-3-methylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 114092-31-8 (2S,4S,6S,8R,9S)-2-<(5R)-4-(dimethyl-t-butylsiloxy)>-2-<(5R,2E)-6-hydroxy-3,5-dimethylhex-2-enyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 82045-55-4 (2S,4S,6S,8R,9S)-4-(dimethyl-t-butylsiloxy)-2-<(5R,2E,6E/Z,8E)-9-(5-methoxycarbonyl-p-tolyl)-3,5dimethyldeca-2,6,8-trienyl>-8,9-dimethyl-1,7-dioxaspiro<5.5>undecane 
• 82109-86-2 (E)-(R)-6-((2S,4R,6S,8S,9R)-4-Benzyloxy-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl)-2,4-dimethyl-hex-4-enoic acid 

Downstream Products

• 82045-35-0 O-methylmilbemycin 

Relevant academic research and scientific papers

The Total Synthesis of (+)-Milbemycin β3

We report the total synthesis of (+)-milbemycin β3 from the optically pure precursors spiroacetal (3) and vinyl iodide (2), and the aromatic aldehyde (4).

Total Synthesis of (+)-Milbemycin β3

The total synthesis of (+)-milbemycin β3 has been achieved in two ways beginning from the appropriate spiroacetal moiety.In the first, coupling of a vinyl-lithium derivative (18) with the spiroacetal aldehyde (19), available from Swern oxidatio

A Directed Aldol Approach to (+)-Milbemycin β3

Key steps in a total synthesis of (+)-milbemycin β3 are the construction of the 1,7-dioxaspiroundecane (10) by a Lewis acid-catalysed intramolecular directed aldol reaction and the use of sulphone-based olefination reactions for the constr

A Synthesis of (+)-Milbemycin β3. The Directed Aldol Approach

A synthesis of (+)-milbemycin β3, is reported in which key steps are the construction of the 1,7-dioxaspiroundecane (15) by a Lewis acid-catalysed intramolecular directed aldol reaction and the use of sulphone-based olefination reactions f