101214-22-6Relevant articles and documents
Synthesis and structural characterization of triple-helical peptided which mimic the ligand binding site of the human macrophage scavenger receptor
Hojo, Hironobu,Akamatsu, Yoshiko,Yamauchi, Kiyoshi,Kinoshita, Masayoshi,Miki, Shunji,Nakamura, Yu
, p. 14263 - 14274 (1997)
A synthetic method for triple-helical peptides was developed. Peptides with and without glutamic acid a-thioester at their N-termini are prepared by the solid-phase method. These peptides are crosslinked at their N-termini one by one to generate trimeric peptides using the activation of the thioester group by silver ions. This method was applied to the synthesis of model peptides, which mimic the binding site of modified low density lipoprotein (LDL) in the human scavenger receptor (SR). These models possessed different spacers, which connect the peptide chains and the crosslinking site. CD and DSC analysis of the peptides revealed that spacer length has a critical effect on the stability of the triple helix.
ANTI-CD40 ANTIBODY DRUG CONJUGATES
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Paragraph 00191, (2019/06/17)
Provided herein are anti-CD40 antibody drug conjugates comprising a radical of Formula (I), wherein R1, R2, and R3 are as defined herein. Further provided are anti-CD40 antibody drug conjugates of Formula (II), wherein Z, R, AA1, AA2, AA3, m, p, q, n, w, R1, R2, and R3 are as defined herein. Further provided are pharmaceutical compositions and kits thereof, and methods of using same.