101258-16-6

Basic information

• Product Name: 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE
• Synonyms: Ethanone,1-(2-aMino-4-thiazolyl)-;1-(2-amino-4-thiazolyl)ethanone;Ketone 2-amino-4-thiazolyl methyl
• CAS NO: 101258-16-6
• Molecular Formula: C₅H₆N₂OS
• Molecular Weight: 142.18
• Mol File: 101258-16-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 230 °C
• Boiling Point: 303.1°Cat760mmHg
• Flash Point: 137.1°C
• Appearance: white powder
• Density: 1.341g/cm³
• Vapor Pressure: 0.000948mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.41±0.10(Predicted)
• CAS DataBase Reference: 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE(101258-16-6)
• EPA Substance Registry System: 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE(101258-16-6)

Safety Data

• Hazardous Substances Data: 101258-16-6(Hazardous Substances Data)

Usage

General Description

1-(2-Amino-1,3-thiazol-4-yl)ethanone, also known as ethyl 2-amino-4-thiazolyl ketone, is a chemical compound with the formula C5H7N3OS. It is a heterocyclic compound that contains a thiazole ring and an amino group. 1-(2-Amino-1,3-thiazol-4-yl)ethanone is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It exhibits a wide range of biological activities and is used as a building block in the development of new drugs. It is also used in chemical research for the study of thiazole-containing compounds and their potential applications in medicine and agriculture. Additionally, it has applications in the food and beverage industry as a flavor or fragrance ingredient.

InChI:InChI=1/C5H6N2OS/c1-3(8)4-2-9-5(6)7-4/h2H,1H3,(H2,6,7)

Upstream product

• 5308-51-0 1-bromobutane-2,3-dione 
• 17356-08-0 thiourea 
• 431-03-8 dimethylglyoxal 
• 116008-78-7 1-(2-amino-thiazol-4-yl)-ethanone; hydrochloride 
• 762271-84-1 (4-Acetyl-thiazol-2-yl)-carbamic acid tert-butyl ester 
• 5559-62-6 1-chloro-2,3-dioxo-butane 

Downstream Products

• 876754-81-3 [(1S,2S)-1-(4-acetyl-thiazol-2-ylcarbamoyl)-2-phenyl-propyl]-carbamic acid tert-butyl ester 
• 1187540-89-1 N-{1-[2-(cyclopropylethynyl)-1,3-thiazol-4-yl]ethoxy}-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine 
• 1187540-88-0 N-[1-(2-bromo-1,3-thiazol-4-yl)ethoxy]-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine 

Relevant articles and documents

Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers

Small molecule ligand binding to the ATAD2 bromodomain is investigated here through the synergistic combination of molecular dynamics and protein crystallography. A previously unexplored conformation of the binding pocket upon rearrangement of the gatekeeper residue Ile1074 has been found. Further, our investigations reveal how minor structural differences in the ligands result in binding with different plasticity of the ZA loop for this difficult-to-drug bromodomain.

Substituted hydantoins

The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.

NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES

The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein X1 represents a nitrogen atom, sulfur atom, oxygen at