101258-96-2

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 14, p. 862, 1949 DOI: 10.1021/jo01157a020

InChI:InChI=1/C8H17NO/c1-8(2,7-10)9-5-3-4-6-9/h10H,3-7H2,1-2H3

Upstream product

• 32515-32-5 methyl-2 (pyrrolidinyl-1)-2 propanoate d'ethyle 
• 110-52-1 1,4-dibromo-butane 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 1346700-81-9 6-{2-[4-(1,1-dimethyl-2-pyrrolidin-1-yl-ethoxy)phenyl]benzoxazol-6-yl}-5-ethyl-4,5-dihydro-2H-pyridazin-3-one 
• 36946-70-0 indoleamine 
• 459449-48-0 2-Methyl-5-(2-methyl-2-pyrrolidin-1-yl-propoxy)-1H-indole-3-carboxylic acid benzyl ester 
• 114281-41-3 1-(3-carbamoyl-1,1-dimethyl-3,3-diphenyl-propyl)-1-methyl-pyrrolidinium; bromide 
• 114278-72-7 4-methyl-2,2-diphenyl-4-pyrrolidino-valeric acid amide 
• 113058-45-0 4-methyl-2,2-diphenyl-4-pyrrolidino-valeronitrile 
• 95619-39-9 2,6-dimethyl-4-propoxy-benzoic acid-(β-pyrrolidino-isobutyl ester) 

Relevant academic research and scientific papers

Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

A series of benzoxathiin SERAMs was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue. A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.

Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor

Disclosed are novel compounds having the formula or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4'' side chain

The preparation and biological evaluation of a series of benzo[b]thiophene diamine thrombin inhibitors possessing conformationally restricted C-4'' linkers are reported. Compared to the parent compounds 1a/b, the unsaturated derivatives 3a/b exhibited a m