101290-91-9Relevant academic research and scientific papers
A 3 - cyano indole synthetic method of the compound
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Paragraph 0010; 0011; 0012; 0013-0030; 0040-0042, (2017/08/25)
The invention discloses a method for synthesizing a 3-cyanoindole compound and belongs to the technical field of synthetic technology. The technical solution provided by the invention is characterized that the method for synthesizing the 3-cyanoindole com
Photochemical C–H Activation: Generation of Indole and Carbazole Libraries, and First Total Synthesis of Clausenawalline D
Alimi, Isak,Remy, Richard,Bochet, Christian G.
, p. 3197 - 3210 (2017/06/21)
The photolysis of N-aryltriazoles and N-arylbenzotriazoles leads to indoles and carbazoles, respectively. Because libraries of triazoles can be accessed rapidly, for example by the copper-catalyzed [3+2] cycloaddition reaction between alkynes and azides, this reaction allows the preparation of indoles in a single operation, by the simultaneous photolysis of the precursor library. As an example of such a synthesis of carbazoles, we prepared for the first time clausenawalline D, an antimalarial alkaloid that was recently isolated.
PROCESSES FOR PREPARING INDOLES
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Paragraph 00102, (2013/07/05)
Methods for the synthesis of an indole in provided. Methods comprise oxidizing a N-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent.
Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: Indole synthesis from anilines and ketones
Wei, Ye,Deb, Indubhusan,Yoshikai, Naohiko
supporting information; experimental part, p. 9098 - 9101 (2012/07/14)
We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.
PIDA-mediated oxidative C-C bond formation: Novel synthesis of indoles from n-aryl enamines
Yu, Wenquan,Du, Yunfei,Zhao, Kang
supporting information; experimental part, p. 2417 - 2420 (2009/11/30)
A variety of functionalized indoles were synthesized from N-aryl enamines via PIDA-mediated oxidative carbon-carbon bond formation. The features of the present reaction include facilitative preparation of substrates 2, good functional group tolerance, and mild reaction conditions without transition metals.
