101290-91-9

Basic information

• Product Name: 5-methoxy-2-phenyl-1H-indole-3-carbonitrile
• Synonyms: 5-methoxy-2-phenyl-1H-indole-3-carbonitrile
• CAS NO: 101290-91-9
• Molecular Weight: 248.284
• Mol File: 101290-91-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-methoxy-2-phenyl-1H-indole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-2-phenyl-1H-indole-3-carbonitrile(101290-91-9)
• EPA Substance Registry System: 5-methoxy-2-phenyl-1H-indole-3-carbonitrile(101290-91-9)

Safety Data

• Hazardous Substances Data: 101290-91-9(Hazardous Substances Data)

Upstream product

• 2101-87-3 p-methoxy-phenylazide 
• 614-16-4 Benzoylacetonitrile 
• 69689-99-2 3-((4-methoxyphenyl)amino)-3-phenylacrylonitrile 

Relevant articles and documents

Photochemical C–H Activation: Generation of Indole and Carbazole Libraries, and First Total Synthesis of Clausenawalline D

The photolysis of N-aryltriazoles and N-arylbenzotriazoles leads to indoles and carbazoles, respectively. Because libraries of triazoles can be accessed rapidly, for example by the copper-catalyzed [3+2] cycloaddition reaction between alkynes and azides, this reaction allows the preparation of indoles in a single operation, by the simultaneous photolysis of the precursor library. As an example of such a synthesis of carbazoles, we prepared for the first time clausenawalline D, an antimalarial alkaloid that was recently isolated.

PROCESSES FOR PREPARING INDOLES

Methods for the synthesis of an indole in provided. Methods comprise oxidizing a N-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent.

PIDA-mediated oxidative C-C bond formation: Novel synthesis of indoles from n-aryl enamines

A variety of functionalized indoles were synthesized from N-aryl enamines via PIDA-mediated oxidative carbon-carbon bond formation. The features of the present reaction include facilitative preparation of substrates 2, good functional group tolerance, and mild reaction conditions without transition metals.