2101-87-3

Usage

InChI:InChI=1/C7H7N3O/c1-11-7-4-2-6(3-5-7)9-10-8/h2-5H,1H3

Upstream product

• 1516-21-8 4-methoxynitrosobenzene 
• 32785-42-5 para-methoxyphenyl pentazole 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 20265-97-8 p-anisidine hydrochloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 
• 5720-07-0 4-methoxyphenylboronic acid 
• 104-94-9 4-methoxy-aniline 
• 150-76-5 4-methoxy-phenol 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 171364-79-7 2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1246367-30-5 benzotriazol-1-yl-sulfonyl azide 
• 100-17-4 para-methoxynitrobenzene 
• 1205534-16-2 2-azido-1,3-dimethylimidazolinium chloride 

Downstream Products

• 108841-98-1 1-(4-methoxyphenyl)-4-phenyl-1H-1,2,3-triazol-5-amine 
• 2592-28-1 4-[(4-methoxyphenyl)azo]aniline 
• 14796-89-5 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline 
• 1210-42-0 3-(4-methoxy-phenyl)-(3ar,6ac)-3a,5,6,6a-tetrahydro-3H-furo[2,3-d][1,2,3]triazole 
• 94258-14-7 4-Methoxy-4'-phenyl-azobenzol 
• 2034-27-7 4-[3-(4-methoxy-phenyl)-4-phenyl-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine 
• 104-94-9 4-methoxy-aniline 
• 90861-94-2 4-methoxy-2-tetrahydro-2-thienylaniline 
• 139871-53-7 1-(4-Methoxyphenyl)-5-(2-oxo-1-pyrrolidinyl)-1,2,3-triazoline 
• 542-92-7 cyclopenta-1,3-diene 
• 55949-76-3 Cyclopenta-2,5-diene-1,2-dicarboxylic acid dimethyl ester 
• 68535-49-9 1-(4-methoxyphenyl)-1H-[1,2,3]triazole 
• 4953-05-3 dimethyl 1-(4-methoxyphenyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 624-92-0 Dimethyldisulphide 

Relevant academic research and scientific papers

Transient resonance Raman and density functional theory investigation of 4-methoxyphenylnitrenium and 4-ethoxyphenylnitrenium ions

This paper presents a transient resonance Raman and density functional theory study of 4-methoxyphenylnitrenium and 4-ethoxyphenylnitrenium ions in a largely aqueous environment. The transient Raman bands observed in conjunction with the (U)BPW91/cc-PVDZ

1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies

A new series of triazole-thiazole hybrids were designed, synthesized by the Multi-component reaction approach and evaluated in vitro antimicrobial activity. Most of the tested series of compounds exhibited promising inhibitory activity against the bacteri

Photochemistry of Aryl Pentazoles: Para -Methoxyphenylpentazole

The photolysis of para-methoxyphenyl pentazole (MeOPP) in methylcyanide (MeCN), investigated in the far UV (FUV) and near UV (NUV) is compared with the photolysis of para-methoxyphenyl azide (MeOPA). The main photoproduct of MeOPP is MeOPA, which, due to

The race for the first generation of the pentazolate anion in solution is far from over

The previous claim for the first generation of the pentazolate anion in solution was carefully reexamined; no evidence for the formation of cyclo-N 5- was found under the reported conditions. The Royal Society of Chemistry 2005.

Helicenoid-based bis-1,2,3-triazole tweezer: Synthesis and selective iodide sensing

Novel helicenoid based 1,2,3-triazole tweezer 4 was synthesized using a multistep synthetic protocol with high yields from 2,7-Dihydroxynaphtlene 3 as a precursor. This helicenoid-based bis-1,2,3-triazole tweezer 4 selectively causes non-covalent interact

Combinatorial synthesis of new fluorescent scaffolds using click chemistry

Azides and acetylenes are bio-orthogonal functional groups that can be readily coupled using copper(I)- or ruthenium(II)- catalyzed 1,3-dipolar cycloaddition reactions. Using non-fluorescent aromatic azides and aromatic acetylenes, covering a range of electron rich and poor building blocks, the Huisgen cycloaddition afford 1,4-disubstituted or 1,5-disubstituted 1,2,3-triazoles. Using a combinatorial approach by running reaction in parallel in polypropylene 96-well plates we discovered several new fluorescent 1,2,3-triazoles scaffolds. These compounds show diverse interactions with biomolecules that could find applications in biology in, for example, fluorescence microscopy or biomolecule quantification.

Nickel Boride Catalyzed Reductions of Nitro Compounds and Azides: Nanocellulose-Supported Catalysts in Tandem Reactions

Nickel boride catalyst prepared in situ from NiCl2 and sodium borohydride allowed, in the presence of an aqueous solution of TEMPO-oxidized nanocellulose (0.01 wt%), the reduction of a wide range of nitroarenes and aliphatic nitro compounds. Here we describe how the modified nanocellulose has a stabilizing effect on the catalyst that enables low loading of the nickel salt pre-catalyst. Ni-B prepared in situ from a methanolic solution was also used to develop a greener and facile reduction of organic azides, offering a substantially lowered catalyst loading with respect to reported methods in the literature. Both aromatic and aliphatic azides were reduced, and the protocol is compatible with a one-pot Boc-protection of the obtained amine yielding the corresponding carbamates. Finally, bacterial crystalline nanocellulose was chosen as a support for the Ni-B catalyst to allow an easy recovery step of the catalyst and its recyclability for new reduction cycles.

Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors

Tranylcypromine (TCP)-based structural modifications lead to the discovery of new LSD1 inhibitors, of which compounds 26b and 29b effectively inhibit LSD1 with the IC50 values of 17 and 11 nM, respectively and also show good selectivity over MAO-B. Mechanistic studies showed that compound 29b concentration-dependently induced H3K4me1/2 accumulation in LSD1 overexpressed MGC-803 cells and also inhibited metastasis of MGC-803 cells. Collectively, both compounds could be promising lead compounds for further investigation.

New inha inhibitors based on expanded triclosan and di-triclosan analogues to develop a new treatment for tuberculosis

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has reinforced the need for the development of new anti-TB drugs. The first line drug isoniazid inhibits InhA. This is a prodrug requiring activation by the enzyme KatG. Mutations in KatG have largely contributed to clinical isoniazid resistance. We aimed to design new ‘direct’ InhA inhibitors that obviate the need for activation by KatG, circumventing pre-existing resistance. In silico molecular modelling was used as part of a rational structure-based drug-design approach involving inspection of protein crystal structures of InhA:inhibitor complexes, including the broad spectrum antibiotic triclosan (TCS). One crystal structure exhibited the unusual presence of two triclosan molecules within the Mycobacterium tuberculosis InhA binding site. This became the basis of a strategy for the synthesis of novel inhibitors. A series of new, flexible ligands were designed and synthesised, expanding on the triclosan structure. Low Minimum Inhibitory Concentrations (MICs) were obtained for benzylphenyl compounds (12, 43 and 44) and di-triclosan derivative (39), against Mycobacterium bovis BCG although these may also be inhibiting other enzymes. The ether linked di-triclosan derivative (38) displayed excellent in vitro isolated enzyme inhibition results comparable with triclosan, but at a higher MIC (125 μg mL?1 ). These compounds offer good opportunities as leads for further optimisation.

A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. This article reports on a general approach to label urea derivatives with all carbon isotopes, including14C and11C, based on a Staudinger aza-Wittig sequence. It provides access to all aliphatic/aromatic urea combinations.