101293-71-4Relevant articles and documents
Enantiomeric phosphonate analogs of the paclitaxel C-13 side chain
Wroblewski, Andrzej E.,Piotrowska, Dorota G.
, p. 2037 - 2043 (2007/10/03)
Both enantiomers of syn diethyl 2-(benzoylamino)-1-hydroxy-2- phenylethylphosphonate have been obtained by resolution via O- methylmandelate derivatives. Removal of the resolving ester moiety was easily achieved by ammonolysis with no trace of the retro-Abramov reaction. Absolute configurations of the enantiomeric phosphonate analogs were established from 1H (the Trost model) and 31P NMR data of the O-methylmandelate derivatives.