1013101-49-9

Basic information

• Product Name: C₂₂H₂₅FN₆O₄
• CAS NO: 1013101-49-9
• Molecular Weight: 456.477
• Mol File: 1013101-49-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₅FN₆O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₅FN₆O₄(1013101-49-9)
• EPA Substance Registry System: C₂₂H₂₅FN₆O₄(1013101-49-9)

Safety Data

• Hazardous Substances Data: 1013101-49-9(Hazardous Substances Data)

Upstream product

• 1013099-50-7 5-bromo-4-chloro-2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-methylpyrimidine 
• 856250-60-7 (5-fluoro-6-methoxypyridin-3-yl)boronic acid 
• 1013099-51-8 trans-4-{[5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-methylpyrimidin-4-yl]amino}cyclohexanol 
• 27489-62-9 trans-4-hydroxycyclohexylamine 

Relevant articles and documents

Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series

PI3K, AKT and mTOR, key kinases from a frequently dysregulated PI3K signaling pathway, have been extensively pursued to treat a variety of cancers in oncology. Clinical trials of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR, from 4-methylpyridopyrimidinone series, led to the discovery of a metabolite with a terminal carboxylic acid, PF-06465603. This paper discusses structure-based drug design, SAR and antitumor activity of the MPP derivatives with a terminal alcohol, a carboxylic acid or a carboxyl amide.