101330-11-4

Basic information

• Product Name: (2-Iodoquinolin-3-yl)-methanol
• Synonyms: (2-Iodoquinolin-3-yl)-methanol;(2-iodo-3-quinolinyl)methanol
• CAS NO: 101330-11-4
• Molecular Formula: C₁₀H₈INO
• Molecular Weight: 285.09
• Mol File: 101330-11-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-Iodoquinolin-3-yl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Iodoquinolin-3-yl)-methanol(101330-11-4)
• EPA Substance Registry System: (2-Iodoquinolin-3-yl)-methanol(101330-11-4)

Safety Data

• Hazardous Substances Data: 101330-11-4(Hazardous Substances Data)

Usage

General Description

(2-Iodoquinolin-3-yl)-methanol is a chemical compound that consists of a quinoline ring with an attached iodine atom and a hydroxyl group. It is a white to off-white crystalline powder that is used primarily as an intermediate in the synthesis of pharmaceuticals and organic compounds. (2-Iodoquinolin-3-yl)-methanol has potential uses in the development of new drugs or as a building block for other chemical reactions. It is important to handle and store (2-Iodoquinolin-3-yl)-methanol with caution as it may have certain health and environmental hazards associated with it. Overall, this chemical is a versatile and valuable tool for chemical research and development.

Upstream product

• 103-84-4 Acetanilid 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 80231-40-9 2-iodo-3-quinolinecarboxaldehyde 
• 125917-60-4 2-chloro-3-(hydroxymethyl)quinoline 

Downstream Products

• 13669-51-7 3-Hydroxymethylquinoline 
• 101330-12-5 2-deuterio-3-(hydroxymethyl)quinoline 
• 1198104-76-5 C₁₈H₁₄INO₄S 
• 1198104-83-4 C₁₇H₁₁F₃INO₂S 
• 1198104-75-4 C₁₇H₁₄INO₂S 
• 127183-70-4 2-benzoyl-3-(hydroxymethyl)quinoline 
• 929803-52-1 N-cyano-N-[(2-iodoquinolin-3-yl)methyl]benzamide 
• 929803-51-0 N-[(2-iodoquinolin-3-yl)methyl]benzamide 
• 127183-66-8 2-iodo-3-(hydroxymethyl)quinoline benzoate ester 

Relevant articles and documents

Vinyl isocyanates in alkaloid synthesis. Camptothecin model studies

Model studies directed toward camptothecin employing a vinyl isocyanateenamine cyclocondensation as the key synthetic step are reported.

Intermediates and method of making camptothecin and camptothecin analogs

Compounds of Formula I STR1 are made in accordance with the following scheme: STR2 wherein R may be loweralkyl; R1 may be H, loweralkyl, loweralkoxy, or halo; R2, R3, R4, and R5 may each independently be H, amino, hydroxy, loweralkyl, loweralkoxy, loweralkylthio, di(loweralkyl)amino, cyano, methylenedioxy, formyl, nitro, halo, trifluoromethyl, aminomethyl, azido, amido, hydrazino, or any of the twenty standard amino acids bonded to the A ring via the amino-nitrogen atom; Y is H and W and X are halogen. Also disclosed are novel processes for making starting materials for the scheme given above, and novel intermediates employed in these processes.

Evidence in favor of lithium-halogen exchange being faster than lithium-acidic hydrogen (deuterium) exchange

Treatment of 2-iodo-3-(deuterioxymethyl)quinoline with 1.5 equiv of n-butyllithium in ether, followed by aqueous work up, furnished 2-deuterio-3-(hydroxymethyl)quinoline in greater than 50% yield, confirming our earlier report,2 which has been