80231-40-9

Basic information

• Product Name: 2-Iodoquinoline-3-carbaldehyde
• Synonyms: 2-Iodoquinoline-3-carbaldehyde
• CAS NO: 80231-40-9
• Molecular Formula: C₁₀H₆INO
• Molecular Weight: 283.07
• Mol File: 80231-40-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 150-152 °C(Solv: ethanol (64-17-5))
• Boiling Point: 388.7±27.0 °C(Predicted)
• Appearance: /
• Density: 1.880±0.06 g/cm3(Predicted)
• PKA: -0.05±0.50(Predicted)
• CAS DataBase Reference: 2-Iodoquinoline-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodoquinoline-3-carbaldehyde(80231-40-9)
• EPA Substance Registry System: 2-Iodoquinoline-3-carbaldehyde(80231-40-9)

Safety Data

• Hazardous Substances Data: 80231-40-9(Hazardous Substances Data)

Upstream product

• 103-84-4 Acetanilid 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 

Downstream Products

• 101330-11-4 (2-iodoquinolin-3-yl)methanol 
• 30125-83-8 2-benzyl-2,3-dihydro-1H-pyrrolo[3,4-b]quinoline 
• 26862-71-5 ethyl 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-2-carboxylate 
• 31456-25-4 camptothecin 
• 110351-92-3 (R)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione 
• 7689-03-4 camptothecin 
• 205989-13-5 quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-13-hydroxy-11-one 
• 1289557-85-2 methyl-2-(11-oxo-11,13-dihydroquinolino[2',3':3,4]pyrrolo[2,1-b]quinazolin-13-yl)amino benzoate 
• 1280722-19-1 ethyl 4-(2-(cyclohex-1-en-1-ylethynyl)quinolin-3-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 13669-51-7 3-Hydroxymethylquinoline 
• 694452-82-9 3-ethoxycarbonylmethyl-1,3-dihydro-pyrrolo[3,4-b]quinoline-2-carboxylic acid benzyl ester 

Relevant articles and documents

A special o-dialdehyde fluorescent probe simultaneously sensing Hcy, GSH and its application in living cells and zebrafish imaging

The development of fluorescent probes enabling to distinguish Cys, Hcy and GSH has always been a considerable challenge, in particular the distinction of Hcy and other two biothiols, because Hcy has a very similar structure with Cys and a relatively lower concentration in living organisms. In this work, a special o-dialdehyde fluorescent probe, quinoline-2,3-dicarboxaldehyde (QDA), has been synthesized and demonstrated superior performance in differentiating detection of Hcy and GSH, which is different from the previous reported o-dialdehyde probes specifically detecting GSH. Furthermore, the probe can selectively distinguish Hcy and GSH from different signal channels in living cells and zebrafish, meaning it has great potential in biological applications. This finding will provide a novel idea for the design of fluorescent probes to distinguish biothiols.

Synthesis of indolizinoquinolinones through three- and four-component domino Knoevenagel / hetero-Diels–Alder reactions: novel access to (+)-camptothecin

[Figure not available: see fulltext.] The fused heterocyclic indolizinoquinolinone system is a key structural feature of several highly bioactive alkaloids, including camptothecin. Camptothecin has been efficiently obtained by a three- or four-component domino Knoevenagel / hetero-Diels–Alder reaction of aldehyde, Meldrum's acid, and enol ether in the presence or absence of alcohol, followed by reductive cleavage of the amine protecting group. The obtained products were further transformed along several different routes leading to camptothecin.

Multicomponent approach for the synthesis of phenanthridine and acridine ring systems via the coupling of fischer carbene complexes with hetero-aromatic o-alkynyl carbonyl derivatives

A one-pot multicomponent synthesis of phenanthridine and acridine derivatives is described. This method includes the in situ generation of furo[3,4-c]isoquinoline and furo[3,4-b]quinoline intermediates by the coupling of heteroaromatic o-alkynyl carbonyl derivatives with Fischer carbene complexes and subsequent trapping of these intermediates by suitable dienophiles. Georg Thieme Verlag Stuttgart - New York.