1013355-29-7Relevant articles and documents
New cinnamic acid-pregenolone hybrids as potential antiproliferative agents: Design, synthesis and biological evaluation
Ge, Yong-Xi,Wang, Yan-Hong,Zhang, Juan,Yu, Zhi-Pu,Mu, Xin,Song, Jia-Li,Wang, Yin-Yin,Yang, Feifei,Meng, Ning,Jiang, Cheng-Shi,Zhang, Hua
, (2019)
A series of new cinnamic acid-pregenolone hybrids (5a-5o) was designed, synthesized and evaluated for their in vitro antiproliferative activity. Some of them showed potential antiproliferative activity and selectivity towards a panel of cancer cell lines,
Design and synthesis of pregnenolone/2-cyanoacryloyl conjugates with dual NF-κB inhibitory and anti-proliferative activities
Song, Jia-Li,Zhang, Juan,Liu, Chang-Liang,Liu, Chao,Zhu, Kong-Kai,Yang, Fei-Fei,Liu, Xi-Gong,Figueiró Longo, Jo?o Paulo,Alexandre Muehlmann, Luis,Azevedo, Ricardo Bentes,Zhang, Yu-Ying,Guo, Yue-Wei,Jiang, Cheng-Shi,Zhang, Hua
, p. 4682 - 4686 (2017)
Twenty-five novel pregnenolone/2-cyanoacryloyl conjugates (6–30) were designed and prepared, with the aim of developing novel anticancer drugs with dual NF-κB inhibitory and anti-proliferative activities. Compounds 22 and 27–30 showed inhibition against T