1013388-00-5Relevant articles and documents
MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes
Er, Jun Cheng,Tang, Mui Kee,Chia, Chee Geng,Liew, Huimin,Vendrell, Marc,Chang, Young-Tae
, p. 2168 - 2176 (2013)
A novel class of triazole-derivatized BODIPY compounds have been synthesized on solid-phase by employing mild reaction conditions based on the copper-catalyzed azide-alkyne cycloaddition. The resulting BODIPY-triazoles exhibited MegaStokes shifts (up to 160 nm) and remarkable environmentally sensitive quantum yield increments that asserted their potential as turn-on fluorescent sensors. Out of a library of 120 compounds, we identified BDC-9 as a fluorescent chemosensor with high sensitivity and remarkable species-selectivity towards human serum albumin. These results validate MegaStokes BODIPY dyes as new fluorophores for the development of environmentally sensitive fluorescent probes.