101350-88-3

Basic information

• Product Name: 2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-phenylacetamide
• Synonyms: 2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-phenylacetamide
• CAS NO: 101350-88-3
• Molecular Formula: C₁₆H₁₄N₂O₂S
• Molecular Weight: 298.35956
• Mol File: 101350-88-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 600.1°Cat760mmHg
• Flash Point: 316.7°C
• Appearance: /
• Density: 1.315g/cm³
• Vapor Pressure: 2.33E-14mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-phenylacetamide(101350-88-3)
• EPA Substance Registry System: 2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)-N-phenylacetamide(101350-88-3)

Safety Data

• Hazardous Substances Data: 101350-88-3(Hazardous Substances Data)

Usage

Pharmaceutical Potential

Yes

Properties

+ Antibacterial
+ Disrupts mycobacterial cell wall formation
+ Inhibits bacterial growth
+ Potential to treat tuberculosis, especially when used with other antibiotics
+ Being investigated for potential to overcome drug-resistant strains of tuberculosis
+ Anti-inflammatory
+ Analgesic

Possible Therapeutic Applications

Treatment of tuberculosis, development of new therapeutic agents.

InChI:InChI=1/C16H14N2O2S/c19-15(17-11-6-2-1-3-7-11)10-14-16(20)18-12-8-4-5-9-13(12)21-14/h1-9,14H,10H2,(H,17,19)(H,18,20)

Upstream product

• 6270-74-2 3-oxo-1,4-benzothiazin-2-ylacetic acid 
• 80167-50-6 N-phenyl-maleamic acid methyl ester 
• 555-59-9 N-phenylmaleamic acid 
• 137-07-5 2-amino-benzenethiol 
• 87321-69-5 methyl (E)-4-oxo-4-(phenylamino)but-2-enoate 
• 62-53-3 aniline 
• 19990-26-2 5-(N-phenyl)-imino-5H-furan-2-one 
• 134616-44-7 2(H)-oxo-3,3a-dihydrofuro<3,2-b><1,4> benzothiazine 
• 941-69-5 N-phenyl-maleimide 
• 37902-58-2 3-phenylcarbamoylacrylic acid 

Downstream Products

• 2694-31-7 1-phenyl-3,3a-dihydro-1H-benzo[b]pyrrolo[2,3-e][1,4]thiazin-2-one 

Relevant articles and documents

Synthesis and antifungal activity of N-(alkyl/aryl)-2-(3-oxo-1,4- benzothiazin-2-yl)acetamide

A series of N-(alkyl/aryl)-2-(3-oxo-1,4-benzothiazin-2-yl)acetamide have been synthesized by condensation of substituted amines with maleic anhydride (MA) followed by cyclization with o-aminothiophenol (o-ATP). All the compounds have been screened for their antifungal activity against Tricophyton rubrum, Epidermophyton floccosum and Malassazia furfur. In the primary screening, some of the compounds exhibited appreciable activity. The structures of the synthesized compounds 7a-z have been established on the basis of elemental analysis and spectral data.

REACTIONS OF o-AMINOTHIOPHENOL WITH α,β-UNSATURATED DICARBONYL SYSTEMS. FACILE SYNTHESIS OF BENZOTHIAZINES AND BENZOTHIAZEPINES

When treated with maleanilic/fumaranilic acids or esters or the corresponding imides or isoimides, o-aminothiophenol furnishes benzothiazines, whereas treatment of o-aminothiophenol with acrylic acids/esters furnishes benzothiazepines.The orientational pr