1013905-81-1

Basic information

• Product Name: N-methyl-N-(2-methylphenyl)-3-phenylpropynamide
• Synonyms: N-methyl-N-(2-methylphenyl)-3-phenylpropynamide
• CAS NO: 1013905-81-1
• Molecular Weight: 249.312
• Mol File: 1013905-81-1.mol

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(2-methylphenyl)-3-phenylpropynamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(2-methylphenyl)-3-phenylpropynamide(1013905-81-1)
• EPA Substance Registry System: N-methyl-N-(2-methylphenyl)-3-phenylpropynamide(1013905-81-1)

Safety Data

• Hazardous Substances Data: 1013905-81-1(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 637-44-5 phenylpropyolic acid 
• 74-88-4 methyl iodide 
• 591-50-4 iodobenzene 
• 611-21-2 N,2-dimethylaniline 

Downstream Products

• 1021443-31-1 3-iodo-1,8-dimethyl-4-phenylquinolin-2(1H)-one 
• 1384559-60-7 3-(hydroxy(phenyl)methylene)-1,7-dimethylindolin-2-one 
• 1607433-09-9 3-(4-methoxybenzoyl)-1,6-dimethyl-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione 
• 91790-39-5 N,7-dimethylindoline-2,3-dione 
• 65-85-0 benzoic acid 
• 1364232-11-0 3-bromo-1,6-dimethyl-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione 
• 1364232-13-2 3-iodo-1,6-dimethyl-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione 
• 1194813-04-1 (E)-3-benzylidene-1,7-dimethylindolin-2-one 
• 1194813-02-9 (Z)-3-benzylidene-1,7-dimethylindolin-2-one 
• 1185649-79-9 (E)-2-(N-methyl-N-o-tolylcarbamoyl)-1-phenylvinyl pivalate 
• 1185649-69-7 1,8-dimethyl-3,4-diphenylquinolin-2(1H)-one 
• 1185649-93-7 1,7-dimethyl-3-(diphenylmethylene)indolin-2-one 

Relevant articles and documents

Visible light induced the high-efficiency spirocyclization reaction of propynamide and thiophenols via recyclable catalyst Pd/ZrO2

A new method for the synthesis of 3-thioazaspiro[4,5]trienones was developed using Pd nanoparticle catalysts, which are highly efficient, environmentally friendly and recyclable. Alkynes and thiophene phenols are effectively cyclized by Pd/ZrO2

Visible-light-mediated selective thiocyanation/ipso-cyclization/oxidation cascade for the synthesis of thiocyanato-containing azaspirotrienediones

A visible-light-mediated metal-free thiocyanate radical addition/ipso-cyclization/oxidation cascade reaction for the synthesis of thiocyanato-containing azaspirotrienediones from N-phenylpropynamides is described. Cheap and readily available ammonium thiocyanate was used as a precursor to the thiocyanate free radical, which undergoes a radical addition reaction with the alkyne, followed by selective ipso-cyclization and oxidation to afford the dearomatized products. No product of ortho-cyclization was detected. The reaction completes the synthesis of C–S, C–C, and C[dbnd]O bonds in one pot, with abundant and renewable air oxygen as the sole sacrificial reagent and oxygen source.

Iodocyclization of n-arylpropynamides mediated by hypervalent iodine reagent: Divergent synthesis of iodinated quinolin-2-ones and spiro[4,5]trienones

PhI(OCOCF3)2 acts as both a nonmetal oxidant and an iodination reagent to trigger iodocyclization of N-arylpropynamides while selectively affording iodinated quinolin-2-ones or the spiro[4,5]trienone skeleton, depending on the substituent pattern. In cases where the Narylpropynamide bears a para-fluorine on the aniline ring, the spiro compound is formed via an exclusive defluorination process; otherwise, the product was quinolin-2-one.

Copper-catalyzed difunctionalization of activated alkynes by radical oxidation-tandem cyclization/dearomatization to synthesize 3-trifluoromethyl spiro[4.5]trienones

A copper-catalyzed difunctionalizing trifluoromethylation of activated alkynes with the cheap reagent sodium trifluoromethanesulfinate (NaSO2CF3 or Langlois' reagent) has been developed incorporating a tandem cyclization/ dearomatiza

Catalytic oxidation/C-H functionalization of N-arylpropiolamides by means of gold carbenoids: Concise route to 3-acyloxindoles

An efficient catalytic C-H functionalization by means of gold carbenoids for the one-step synthesis of 3-acyloxindole derivatives has been developed. The reaction proceeds efficiently with extremely good substrate scope and significant opportunities for s