10140-97-3

Usage

Uses

Used in Pharmaceutical Industry:
α-Chloro-p-nitrostyrene is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its reactivity allows for the creation of diverse chemical structures, enhancing the range of potential medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, α-Chloro-p-nitrostyrene is employed as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its role in synthesizing these compounds helps improve agricultural productivity and crop protection.
Used in Dye Synthesis:
α-Chloro-p-nitrostyrene is used as a precursor in the synthesis of dyes, contributing to the development of new colorants for various applications, including textiles, plastics, and printing inks.
Used in Organic Chemistry Research:
As a versatile intermediate, α-Chloro-p-nitrostyrene is used in organic chemistry research to explore new reaction pathways and develop innovative synthetic methods, further expanding the scope of organic synthesis.
It is crucial to handle α-Chloro-p-nitrostyrene with care, as it is a potentially hazardous and toxic substance. Its use should be restricted to qualified professionals in a controlled laboratory environment to ensure safety and proper utilization.

InChI:InChI=1/C8H6ClNO2/c1-6(9)7-2-4-8(5-3-7)10(11)12/h2-5H,1H2

Upstream product

• 2216-24-2 3-(4-nitrophenyl)-2-propynoic acid 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 2010-59-5 1-(1,2-dichloroethyl)-4-nitrobenzene 
• 100-19-6 (4-nitrophenyl)ethanone 

Relevant academic research and scientific papers

Chloride-tolerant gold(I)-catalyzed regioselective hydrochlorination of alkynes

We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-b

Facile conversion of aldehydes and ketones to gem-dichlorides using chlorodiphenylphosphine/N-chlorosuccinimide as a new and neutral system

Aldehydes and ketones are easily converted to their corresponding gem-dichlorides using a mixture of chlorodiphenylphosphine and N-chlorosuccinimide (ClPPh2/NCS) in dichloromethane under neutral conditions and at room temperature. Copyright Taylor & Francis Group, LLC.

Halogenation through Deoxygenation of Alcohols and Aldehydes

An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols (including tertiary alcohols) and aldehydes. The easily available 1,2-dihaloethanes were used as key reagents and halogen sources. The use of (EtO)3P instead of Ph3P could also realize deoxy-halogenation, allowing for a convenient purification process, as the byproduct (EtO)3Pa?O could be removed by aqueous washing. The mild reaction conditions, wide substrate scope, and wide availability of 1,2-dihaloethanes make this protocol attractive for the synthesis of halogenated compounds.

Synthesis of Vinyl Chlorides via Triphosgene-Pyridine Activation of Ketones

Herein, we describe a mild method to prepare aliphatic and aromatic vinyl chlorides from their corresponding ketones via triphosgene-pyridine activation in dichloromethane at reflux. The mechanism of this reaction is proposed to involve formation of a put

Selective Ruthenium-Catalyzed Hydrochlorination of Alkynes: One-Step Synthesis of Vinylchlorides

An unprecedented ruthenium-catalyzed direct and selective alkyne hydrochlorination is reported and leads to vinylchlorides in excellent yields with atom economy. The reaction proceeds at room temperature from terminal alkynes and provides a variety of chloroalkenes. Only the regioisomer resulting from the formal Markovnikov addition is selectively formed. Mechanistic studies show the stereoselective syn addition of HCl to alkynes at room temperature and suggest a chloro hydrido RuIV species as a key intermediate of the reaction.