10140-97-3

Basic information

• Product Name: α-Chloro-p-nitrostyrene
• Synonyms: α-Chloro-p-nitrostyrene
• CAS NO: 10140-97-3
• Molecular Formula: C₈H₆ClNO₂
• Molecular Weight: 183.59174
• Mol File: 10140-97-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 63.5°C
• Boiling Point: 265.9°Cat760mmHg
• Flash Point: 114.6°C
• Appearance: /
• Density: 1.3248 (rough estimate)
• Vapor Pressure: 0.0146mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• CAS DataBase Reference: α-Chloro-p-nitrostyrene(CAS DataBase Reference)
• NIST Chemistry Reference: α-Chloro-p-nitrostyrene(10140-97-3)
• EPA Substance Registry System: α-Chloro-p-nitrostyrene(10140-97-3)

Safety Data

• Hazardous Substances Data: 10140-97-3(Hazardous Substances Data)

Usage

General Description

α-Chloro-p-nitrostyrene is a chemical compound with the molecular formula C8H6ClNO2. It is a pale yellow solid that is primarily used as a building block in the synthesis of various organic compounds, particularly in the production of pharmaceuticals and agrochemicals. α-Chloro-p-nitrostyrene is a versatile intermediate in organic chemistry, and it is valued for its ability to undergo a variety of reactions, such as Nucleophilic substitution, Michael addition, and reduction. It is also used in the synthesis of dyes and as a precursor for the preparation of functionalized organic compounds. However, it is important to handle α-Chloro-p-nitrostyrene with caution, as it is a potentially hazardous and toxic substance and should only be used by qualified professionals in a controlled laboratory environment.

InChI:InChI=1/C8H6ClNO2/c1-6(9)7-2-4-8(5-3-7)10(11)12/h2-5H,1H2

Upstream product

• 100-19-6 (4-nitrophenyl)ethanone 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 2216-24-2 3-(4-nitrophenyl)-2-propynoic acid 
• 2010-59-5 1-(1,2-dichloroethyl)-4-nitrobenzene 

Relevant articles and documents

Chloride-tolerant gold(I)-catalyzed regioselective hydrochlorination of alkynes

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Halogenation through Deoxygenation of Alcohols and Aldehydes

An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols (including tertiary alcohols) and aldehydes. The easily available 1,2-dihaloethanes were used as key reagents and halogen sources. The use of (EtO)3P instead of Ph3P could also realize deoxy-halogenation, allowing for a convenient purification process, as the byproduct (EtO)3Pa?O could be removed by aqueous washing. The mild reaction conditions, wide substrate scope, and wide availability of 1,2-dihaloethanes make this protocol attractive for the synthesis of halogenated compounds.

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