101417-79-2

Upstream product

• 101417-78-1 1-(2,5-dimethoxyphenyl)-1,3-dideoxy-2-C-(hydroxymethyl)-2,2':4,5-di-O-isopropylidene-D-ribitol 
• 77-76-9 2,2-dimethoxy-propane 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 93662-51-2 3-deoxy-2(R),4(S)-2-C-hydroxymethyl-2,2':4,5-di-O-isopropylidene-D-glycero-pentitol 
• 101417-77-0 (2S,4S)-1-(2,5-dimethoxyphenyl)-1,2,4,5-tetrahydroxy-3-deoxy-1-O-<(methylthio)thiocarbonyl>-2-(hydroxymethyl)-2,2':4,5-di-O-isopropylidenepentitol 
• 101417-76-9 (2S,4S)-1-(2,5-dimethoxyphenyl)-1,2,4,5-tetrahydroxy-3-deoxy-2-(hydroxymethyl)-2,2':4,5-di-O-isopropylidenepentitol 
• 101417-75-8 (-)-(2S,4S)-methyl 2,4,5-trihydroxy-2-(hydroxymethyl)-2,2':4,5-di-O-isopropylidenepentanoate 
• 93662-54-5 3-deoxy-2-C-(hydroxymethyl)-2,2':4,5-di-O-isopropylidene-D-ribose 

Downstream Products

• 101417-80-5 (+)-(3S)-4-(2,5-dimethoxyphenyl)-3-hydroxy-3-(hydroxymethyl)-3,3'-O-isopropylidenebutanal 

Relevant academic research and scientific papers

Anthracyclinones. 3. Chiral Pool Synthesis of Anthracyclinones via Tetralin Intermediates

The synthesis of AB ring segments 14, 15, and 28 of anthracyclinones involves in a key step an ortho-alkylation of bromodimethoxybenzene 5 (X = Br) with chiral aldehydes 6 or 19, which are themselves prepared from the isopropylidene derivative of α-D-isos

CHIRAL POOL SYNTHESIS OF TETRALIN AS AB RING SEGMENT, PRECURSOR OF ANTHRACYCLINES.

A practical synthesis of chiral tetralin 6, an anthracycline precursor, is described, starting from the readily available α-D-isosaccharino-1,4 lactone.