101417-76-9

Upstream product

• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 93662-54-5 3-deoxy-2-C-(hydroxymethyl)-2,2':4,5-di-O-isopropylidene-D-ribose 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 77-76-9 2,2-dimethoxy-propane 
• 93662-51-2 3-deoxy-2(R),4(S)-2-C-hydroxymethyl-2,2':4,5-di-O-isopropylidene-D-glycero-pentitol 
• 101417-75-8 (-)-(2S,4S)-methyl 2,4,5-trihydroxy-2-(hydroxymethyl)-2,2':4,5-di-O-isopropylidenepentanoate 
• 78687-63-5 2,6-O-isopropylidene-α-D-glucoisosaccharino-1,4-lactone 

Downstream Products

• 101417-77-0 (2S,4S)-1-(2,5-dimethoxyphenyl)-1,2,4,5-tetrahydroxy-3-deoxy-1-O-<(methylthio)thiocarbonyl>-2-(hydroxymethyl)-2,2':4,5-di-O-isopropylidenepentitol 
• 101417-80-5 (+)-(3S)-4-(2,5-dimethoxyphenyl)-3-hydroxy-3-(hydroxymethyl)-3,3'-O-isopropylidenebutanal 
• 101417-79-2 (+)-1-(2,5-dimethoxyphenyl)-1,3-dideoxy-2-C-(hydroxymethyl)-2,2'-O-isopropylidene-D-ribitol 
• 101417-78-1 1-(2,5-dimethoxyphenyl)-1,3-dideoxy-2-C-(hydroxymethyl)-2,2':4,5-di-O-isopropylidene-D-ribitol 

Relevant academic research and scientific papers

CHIRAL POOL SYNTHESIS OF TETRALIN AS AB RING SEGMENT, PRECURSOR OF ANTHRACYCLINES.

A practical synthesis of chiral tetralin 6, an anthracycline precursor, is described, starting from the readily available α-D-isosaccharino-1,4 lactone.

Anthracyclinones. 3. Chiral Pool Synthesis of Anthracyclinones via Tetralin Intermediates

The synthesis of AB ring segments 14, 15, and 28 of anthracyclinones involves in a key step an ortho-alkylation of bromodimethoxybenzene 5 (X = Br) with chiral aldehydes 6 or 19, which are themselves prepared from the isopropylidene derivative of α-D-isos