10146-98-2Relevant academic research and scientific papers
A one-pot synthesis of pyrido[2,3-d]- and quinolino[2,3-d]pyrimidines
El-Ahl, Abdel Aziz S.,El Bialy, Serry A.A.,Ismail, Mohamed A.
, p. 1315 - 1321 (2007/10/03)
The in situ formed methylene derivatives of 1,3-dicarbonyl compounds; ethyl cyanoacetate; malononitrile and ketones; react with 6-amino-1,3-dimethyluracil as activated alkenyl derivatives, affording Michael adducts. The adduts simultaneously undergo cyclization to furnish pyrido[2,3-d]- or quinolino[2,3-d]pyrimidine derivatives in high yield.
A Chemical Model of Thymidylate Synthetase. Formation of a Thymine Derivative via an Exocyclic Methylene Intermediate
Meij, Paul F. C. van der,Lohmann, Ruth D.,Waard, Eduard R. de,Chen, Tjoe B. R. A.,Pandit, Upendra K.
, p. 1229 - 1230 (2007/10/02)
Reaction of 6-aminouracil derivatives with imidazolidines (methylenetetrahydrofolate models), in the presence of acid, gives an exocyclic methylene intermediate which reacts with nucleophiles present in the mixture or can be reduced to a thymine derivative.
