1014691-61-2 Usage
Description
3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester is a complex organic compound characterized by its unique chemical structure. It is a derivative of thiophene, a heterocyclic compound with a sulfur atom, and features a sulfonyl group, an amino group, and a methoxy group attached to its phenyl ring. 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester is known for its potential applications in various fields due to its distinct chemical properties.
Uses
Used in Pharmaceutical Industry:
3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester is used as a pharmaceutical compound for its potential therapeutic applications. The compound's unique structure allows it to interact with specific biological targets, making it a promising candidate for the development of new drugs.
Used in Research Applications:
In the field of research, 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester is used as a research tool to study the effects of various compounds on cellular processes. For instance, it has been used to investigate the effects of bezafibrate (BZA) on hypertrophy, providing valuable insights into the underlying mechanisms of the condition.
Used in Antiangiogenic Applications:
3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester is used as an antiangiogenic agent, particularly in the context of oxygen-induced retinopathy. Its ability to regulate tumor necrosis factor-α (TNFα)-induced inflammation in human retinal microvascular endothelial cells (HRMECs) makes it a potential therapeutic option for conditions involving abnormal blood vessel growth.
Biochem/physiol Actions
GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (160 nM). GSK0660 is nearly inactive on PPARα and PPARγ with IC50s greater than 10 μM.
Check Digit Verification of cas no
The CAS Registry Mumber 1014691-61-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,4,6,9 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1014691-61:
(9*1)+(8*0)+(7*1)+(6*4)+(5*6)+(4*9)+(3*1)+(2*6)+(1*1)=122
122 % 10 = 2
So 1014691-61-2 is a valid CAS Registry Number.
1014691-61-2Relevant articles and documents
Organocatalyst-controlled site-selective arene C–H functionalization
Mao, Jian-Hui,Wang, Yong-Bin,Yang, Limin,Xiang, Shao-Hua,Wu, Quan-Hao,Cui, Yuan,Lu, Qian,Lv, Jie,Li, Shaoyu,Tan, Bin
, p. 982 - 991 (2021)
Over the past three decades, organocatalysis has emerged as a powerful catalysis platform and has gradually been incorporated into the routine synthetic toolbox to obtain chiral molecules. However, its application in the site- and enantioselective functionalization of inactive aryl C–H bonds remains in its infancy. Here, we present an organocatalyst-controlled para-selective arene C–H functionalization strategy that addresses this issue, which remains an enduring challenge in arene functionalization chemistry. By emulating enzyme catalysis, the chiral phosphoric acid catalyst offers an ideal chiral environment for stereoinduction, and the projecting substituents give control of chemo- and site-selectivity. Various types of nucleophile are compatible with this method, affording more than 100 para-selective adducts with stereodefined carbon centres or axes in viable molecular contexts. This protocol is expected to provide a general strategy for para-selective functionalization of arene C–H bonds in a controlled manner. [Figure not available: see fulltext.]
