59337-92-7

Basic information

• Product Name: Methyl 3-chlorosulfonylthiophene-2-carboxylate
• Synonyms: METHYL 3-(CHLOROSULFONYL)-2-THIOPHENECARBOXYLATE;METHYL 3-(CHLOROSULPHONYL)THIOPHENE-2-CARBOXYLATE;METHYL 3-CHLOROSULFONYLTHIOPHENE-2-CARBOXYLATE;METHYLCHLOROSULFONYLTHIOPHENECARBOXYLATE;BUTTPARK 27\06-40;2-CARBOMETHOXY-3-THIOPHENESULFONYL CHLORIDE;2-(METHOXYCARBONYL)-3-THIOPHENESULFONYL CHLORIDE;2-(METHOXYCARBONYL)THIOPHENE-3-SULFONYL CHLORIDE
• CAS NO: 59337-92-7
• Molecular Formula: C₆H₅ClO₄S₂
• Molecular Weight: 240.68
• EINECS: 1533716-785-6
• Product Categories: SULFONYLHALIDE;INTERMEDIATESOFTENOXICAM;Sulphonyl Chlorides;Thiophenes & Benzothiophenes;Heterocyclic Compounds;Sulphonyl Chlorides;Thiophenes & Benzothiophenes;Building Blocks;Heterocyclic Building Blocks;Thiophenes;Building Blocks;C4 to C6;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 59337-92-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 61-64 °C(lit.)
• Boiling Point: 364.8 °C at 760 mmHg
• Flash Point: 174.4 °C
• Appearance: White to brown/Crystalline Powder
• Density: 1.568 g/cm³
• Vapor Pressure: 1.65E-05mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• Solubility: soluble in Toluene
• CAS DataBase Reference: Methyl 3-chlorosulfonylthiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-chlorosulfonylthiophene-2-carboxylate(59337-92-7)
• EPA Substance Registry System: Methyl 3-chlorosulfonylthiophene-2-carboxylate(59337-92-7)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3261 8/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 59337-92-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

General Description

2-Carbomethoxy-3-thiophenesulfonyl chloride is widely employed as a sulfonylating reagent. It can be prepared from methyl 3-amino-2-thiophenecarboxylate.

InChI:InChI=1/C6H5ClO4S2/c1-11-6(8)5-4(2-3-12-5)13(7,9)10/h2-3H,1H3

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 59337-91-6 3-chlorosulfonyl-thiophene-2-carboxylic acid chloride 
• 59337-89-2 3-chlorothiophene-2-carboxylic acid 
• 67-56-1 methanol 

Downstream Products

• 106820-63-7 methyl 3-<<<(methoxcarbonyl)methyl>amino>sulfonyl>-2-thiophenecarboxylate 
• 140947-38-2 methyl 3-(N-phenyl-N-methyl)sulfamoylthiophene-2-carboxylate 
• 145865-78-7 C₁₃H₁₂N₂O₄S₂ 
• 145865-79-8 C₁₃H₁₁ClN₂O₄S₂ 
• 145865-77-6 C₁₄H₁₄N₂O₅S₂ 
• 145865-80-1 C₁₄H₁₁N₃O₄S₂ 
• 145865-81-2 C₁₃H₁₁N₃O₆S₂ 
• 373359-62-7 3-[4-(4-oxopiperidin-1-yl)phenylsulfamoyl]thiophene-2-carboxylic acid methyl ester 
• 749268-58-4 3-phenylsulfamoylthiophene-2-carboxylic acid methyl ester 
• 1402049-53-9 3-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)phenylsulfanyl]piperidine-1-sulfonyl}thiophene-2-carboxylic acid methyl ester 
• 1402048-66-1 3-{4-(3,5-di-tert-butyl-4-hydroxyphenylsulfanyl)-4-[3,5-di-tert-butyl-4-(3-hydroxy-propoxy)phenylsulfanyl]piperidine-1-sulfonyl}thiophene-2-carboxylic acid 
• 119120-83-1 1-(1,1-Dioxo-1H-1λ⁶-thieno[2,3-d]isothiazol-3-yl)-1H-benzotriazole 
• 113387-69-2 3-(4-Chloro-3,5-dimethyl-pyrazol-1-yl)-thieno[2,3-d]isothiazole 1,1-dioxide 
• 113387-70-5 1-(1,1-Dioxo-1H-1λ⁶-thieno[2,3-d]isothiazol-3-yl)-1H-indazole 

Relevant articles and documents

Copper-Catalyzed N-Directed Distal C(sp3)-H Sulfonylation and Thiolation with Sulfinate Salts

We herein report a selective and catalytic C(sp3)-H functionalization approach to access amines bearing organo-sulfonyl and organo-thiol groups. This reaction proceeds through a cascade process of N-radical formation, alkyl radical formation via 1,5-HAT, and C-S bond formation, thereby offering a series of functionalized amines. This method could enable primary, secondary, and tertiary C(sp3)-H sulfonylation and thiolation and also exhibits good functional group tolerance.

2,3-Dihydro-3-oxo-thienoisothiazol-1,1-dioxides and their 3-thioxo compounds

2,3-Dihydro-3-oxo-thieno[2,3-d]isothiazole-1,1-dioxide and 2,3-Dihydro-3-oxo-thieno[3,2-d]isothiazole-1,1-dioxide are synthesized. The latter compound can be prepared from 2-chlorothiophene in five steps. Both substances react with Lawessons reagent to give the 3-thioxo derivatives.

Analogues and Derivatives of Tenoxicam. 1. Synthesis and Antiinflammatory Activity of Analogues with Different Residues on the Ring Nitrogen and the Amide Nitrogen

The synthesis of tenoxicam, 4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno-1,2-thiazine-3-carboxamide 1,1-dioxide (1e), and of the analogues with various residues on the ring nitrogen and the amide nitrogen is described.This new class of "oxicams" has pronounced antiinflammatory and analgesic properties.The very specific structure-activity relationship of isomeric and isosteric groups at the amide nitrogen has been evaluated.The substituent in position 2 also has a great influence on the pharmacological properties.Tenoxicam is presently underrgoing clinical trials.