1014697-44-9

Upstream product

• 959698-99-8 methyl 3-[N-(2-iodophenyl)amino]propionate 
• 74-88-4 methyl iodide 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 39891-72-0 methyl 1-methyl-2,3-dihydro-1H-indole-3-carboxylate 
• 108438-43-3 methyl 1-methyl-1H-indole-3-carboxylate 
• 55577-25-8 2-(4-methylphenyl)-1H-indole 
• 1088708-50-2 3-[N-(2-iodophenyl)-N-methylamino]-N-methoxy-N-methylpropanamide 
• 1088708-44-4 3-[N-(2-iodophenyl)-N-methylamino]-N,N-dimethylpropanamide 
• 1088708-55-7 3-[N-(2-iodophenyl)-N-methylamino]-N-methylpropanamide 

Relevant academic research and scientific papers

NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY

The present invention relates to bicyclic compounds (e.g. indoles) containing a sulfonyl moiety, which bind to the liver X receptor (LXRα and/or LΧΚβ) and act preferably as inverse agonists of LXR.

Synthesis of indole-3-carboxylic acid derivatives by Pd(0)-catalyzed intramolecular α-arylation of β-(2-iodoanilino) esters

(Chemical Equation Presented) β-(2-Iodoanilino) esters undergo intramolecular α-arylation in the presence of Pd(PPh3) 4 and potassium phenoxide. The reaction is a useful methodology for the preparation of indole-3-carboxylic acid ester derivatives.