959698-99-8Relevant academic research and scientific papers
NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY
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Page/Page column 158, (2020/01/24)
The present invention relates to bicyclic compounds (e.g. indoles) containing a sulfonyl moiety, which bind to the liver X receptor (LXRα and/or LΧΚβ) and act preferably as inverse agonists of LXR.
Synthesis of indole-3-carboxylic acid derivatives by Pd(0)-catalyzed intramolecular α-arylation of β-(2-iodoanilino) esters
Sole, Daniel,Serrano, Olga
, p. 2476 - 2479 (2008/09/18)
(Chemical Equation Presented) β-(2-Iodoanilino) esters undergo intramolecular α-arylation in the presence of Pd(PPh3) 4 and potassium phenoxide. The reaction is a useful methodology for the preparation of indole-3-carboxylic acid ester derivatives.
Palladium-catalyzed intramolecular nucleophilic substitution at the alkoxycarbonyl group
Sole, Daniel,Serrano, Olga
, p. 7270 - 7272 (2008/09/17)
(Chemical Equation Presented) Coaxed into action: Although ester groups are usually inert towards organopalladium reagents, β-(2-haloanilino)esters undergo intramolecular palladium-catalyzed acylation to give dihydroquinolin-4-ones (see scheme). A four-me
