101475-72-3Relevant academic research and scientific papers
Synthesis of 1,3-aminonaphthols by diastereoselective Betti-type aminoalkylation of dihydroxy naphthalenes; Diastereoselectivity, absolute configuration, and application
Marinova, Maya,Kostova, Kalina,Tzvetkova, Pavleta,Tavlinova-Kirilova, Maya,Chimov, Angel,Nikolova, Rosica,Shivachev, Boris,Dimitrov, Vladimir
, p. 1453 - 1466 (2013)
Dihydroxy naphthalenes have been applied in Betti-type solventless condensation between aldehydes and (S)-phenylethylamine as a chiral auxiliary. A series of chiral 1,3-aminonaphthols has been synthesized and isolated in diastereoisomerically pure form. The absolute configurations of the aminonaphthols synthesized have been determined by means of advanced NMR experiments and confirmed by X-ray crystallography. The new chiral aminonaphthols have been tested as pre-catalysts for the addition of diethyl zinc and alkynyl-Zn-reagents to aldehydes with enantioselectivities of up to 98% ee.
One-pot solvent-free reductive amination with a solid ammonium carbamate salt from CO2 and amine
Kang, Philjun,Lee, Kyu Myung,Lee, Won Koo,Lee, Kyu Hyung,Lee, Byeongno,Cho, Jaeheung,Hur, Nam Hwi
, p. 46203 - 46207 (2015/02/19)
Many amines are liquid and their handling is inconvenient compared with the corresponding solids. We transformed a liquid (S)-(-)-1-phenylethylamine 1 to the corresponding neutral solid form 2 by reacting with carbon dioxide. We performed reductive aminat
Synthesis and dynamics of atropisomeric (S)-N-(α-phenylethyl)benzamides
Huelgas, Gabriela,Bernès, Sylvain,Sánchez, Mario,Quintero, Leticia,Juaristi, Eusebio,Anaya de Parrodi, Cecilia,Walsh, Patrick J.
, p. 12655 - 12664 (2008/03/17)
The synthesis of atropisomeric 2-substituted benzamides 2a-e, 3a-e, and 4a-e, and characterization by X-ray structure analysis of 2d, 2e, 3c, 3e, 4c, and 4e are reported. Dynamic 1H NMR spectroscopic studies of benzamides 2b-d, 3b-d, and 4b-d i
