101479-70-3

Basic information

• Product Name: adaprolol
• Synonyms: Adaprololmaleate; (±)-2-(1-Adamantyl)ethyl (p-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetate Maleate (1:1) (Salt); 2-Tricyclo[3.3.1.13,7]dec-1-ylethyl (4-((2-Hydroxy-3-((1-methylethyl)amino)propyl)oxy)phenyl)acetate (2Z)-2-Butenedioate (Salt); ; 2-tricyclo[3.3.1.1~3,7~]dec-1-ylethyl (4-{2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl)acetate (2Z)-but-2-enedioate (salt)
• CAS NO: 101479-70-3
• Molecular Formula: C₂₆H₃₉NO₄
• Molecular Weight: 545.6643
• Mol File: 101479-70-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 561.6°C at 760 mmHg
• Flash Point: 293.5°C
• Vapor Pressure: 1.89E-13mmHg at 25°C
• CAS DataBase Reference: adaprolol(CAS DataBase Reference)
• NIST Chemistry Reference: adaprolol(101479-70-3)
• EPA Substance Registry System: adaprolol(101479-70-3)

Safety Data

• Hazardous Substances Data: 101479-70-3(Hazardous Substances Data)

Upstream product

• 75-31-0 isopropylamine 
• 114653-12-2 (4-Oxiranylmethoxy-phenyl)-acetic acid 2-adamantan-1-yl-ethyl ester 
• 114653-00-8 [4-(Tetrahydro-pyran-2-yloxy)-phenyl]-acetic acid 2-adamantan-1-yl-ethyl ester 
• 114652-98-1 2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)acetic acid 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 6240-11-5 2-(adamant-1-yl)ethanol 
• 156-38-7 4-hydroxyphenylacetate 
• 114653-06-4 (adamant-1-yl)ethyl 4-hydroxyphenylacetate 
• 114652-97-0 ethyl 4-(2-tetrahydropyranyloxy)phenylacetate 

Relevant articles and documents

Soft Drugs. 7. Soft β-Blockers for Systemic and Ophthalmic Use

The "inactive metabolite approach" used to design a series of "soft" drugs derived from the acidic metabolite of metoprolol.Pharmacokinetic and pharmacodynamic properties of these novel "soft" β-adrenoceptor antagonists were determined: half-lives in human blood ranged from 5 to 754 min.The rates of in vivo disappearance of representative slow, medium, and fast hydrolyzing esters were determined in rats.In each case rapid and quantitative conversion to the corresponding free acid was observed.This suggests a facile, one-step degradation to the predicted major metabolite.The compounds were tested for their ability to decrease intraocular pressure in a rabbit model.Five of the new compounds exerted an ocular hypotensive action comparable to or greater than of the reference compound, timolol maleate, and with a prolonged duration of action in some cases.In contrast the new compounds showed reduced and shorter duration systemic activity.The adamantylethyl ester emerges as a potentially effective antiglaucoma agent with significantly improved site-specific activity.