101495-18-5

Basic information

• Product Name: 4,6-DICHLOROINDOLE
• Synonyms: 4,6-DICHLOROINDOLE;4,6-DICHLORO-1H-INDOLE;1H-Indole, 4,6-dichloro-
• CAS NO: 101495-18-5
• Molecular Formula: C8H5Cl2N
• Molecular Weight: 186.04
• Product Categories: Indole
• Mol File: 101495-18-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 328.146 °C at 760 mmHg
• Flash Point: 182.227 °C
• Appearance: /
• Density: 1.479 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.695
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.20±0.30(Predicted)
• CAS DataBase Reference: 4,6-DICHLOROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLOROINDOLE(101495-18-5)
• EPA Substance Registry System: 4,6-DICHLOROINDOLE(101495-18-5)

Safety Data

• Hazardous Substances Data: 101495-18-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 101495-18-5 differently. You can refer to the following data:
1. 4,6-Dichloro-1H-indole is a dichlorinated indole used in the preparation of various biologically active compounds such as trypase inhibitors and inhibitors of serotonin, norepinephrine, and dopamine r euptake.
2. 4,6-Dichloro-1H-indole is a dichlorinated indole used in the preparation of various biologically active compounds such as trypase inhibitors and inhibitors of serotonin, norepinephrine, and dopamine reuptake.

InChI:InChI=1/C8H5Cl2N/c9-5-3-7(10)6-1-2-11-8(6)4-5/h1-4,11H

Upstream product

• 626-43-7 3,5-Dichloroaniline 
• 103855-01-2 ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate 
• 697-86-9 2,4-dichloro-6-bromoaniline 
• 1391575-68-0 2-(2-bromo-4,6-dichlorophenyl)acetaldehyde 
• 101861-63-6 4,6-dichloro-1H-indole-2-carboxylic acid 
• 53995-82-7 4,6-dichloro-indole-2-carboxylic acid,ethyl ester 

Downstream Products

• 903551-23-5 4,6-dichloroindoline 

Relevant articles and documents

Preparation method for 4,6-dichloroindole

The invention discloses a preparation method for 4,6-dichloroindole. The preparation method comprises the following specific steps: in an acidic condition of 3,5-dichloroaniline, carrying out a diazo-reaction on sodium nitrite and then carrying out a condensation reaction with ethyl pyruvate to obtain ethyl-2-(2-(3,5-dichlorophenyl) hydrazono) propionic acid; carrying out ring formation on the ethyl-2-(2-(3,5-dichlorophenyl) hydrazono) propionic acid under the action of lewis acid to obtain 4,6-dichlorindole ethyl formate; hydrolyzing the 4,6-dichlorindole ethyl formate under action of lithium hydroxide to obtain 4,6-dichloroindolecarboxylic acid; and carrying out decarboxylation on the 4,6-dichloroindolecarboxylic acid to obtain 4,6-dichloroindole. The synthetic process of the inventionis more economic, environmentally friendly, efficient and simple.

Erratum: Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts (Journal of the American Chemical Society (2012) 134 (2466-12469))

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