1015075-01-0Relevant academic research and scientific papers
Efficient preparation of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones
Modha, Sachin G.,Trivedi, Jalpa C.,Mehta, Vaibhav P.,Ermolat'Ev, Denis S.,Van Der Eycken, Erik V.
scheme or table, p. 1614 - 1624 (2012/07/13)
An efficient methodology for the synthesis of tetrasubstituted pyrazines starting from pyrazin-2(1H)-ones has been elaborated. Diversity in the functionalization and the beneficial effect of microwave irradiation throughout the methodology has been demonstrated. Georg Thieme Verlag Stuttgart · New York.
An expeditious route toward pyrazine-containing nucleoside analogues
Modha, Sachin G.,Trivedi, Jalpa C.,Mehta, Vaibhav P.,Ermolat'ev, Denis S.,Van Der Eyckens, Erik V.
scheme or table, p. 846 - 856 (2011/04/17)
An improved and convenient methodology for the synthesis of asymmetrically substituted pyrazines starting from 3,5-dichloropyrazin-2(1H)-ones has been elaborated. Several nucleoside analogues have been synthesized containing the pyrazine core as the organic base coupled with the sugar via a triazole linkage. The beneficial effect of microwave irradiation throughout the sequence has been demonstrated.
A novel and versatile entry to asymmetrically substituted pyrazines
Mehta, Vaibhav Pravinchandra,Sharma, Anuj,Van Hecke, Kristof,Van Meervelt, Luc,Van Der Eycken, Erik
, p. 2382 - 2388 (2008/09/19)
(Chemical Equation Presented) A novel and convenient procedure for the synthesis of asymmetrically tri- and tetrasubstituted pyrazines starting from para-methoxybenzyl-protected 3,5-dichloro-2(1H)-pyrazinones was elaborated. The key step is the conversion
